Cell Biology Antibodies 12

Anti-CALCRL Antibody (CAB8533)

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SKU:
CAB8533
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CALCRL Antibody
Antibody SKU:CAB8533
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 392-461 of human CALCRL (NP_005786.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, MCF7, Mouse kidney, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 392-461 of human CALCRL (NP_005786.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QAIL RRNW NQYK IQFG NSFS NSEA LRSA SYTV STIS DGPG YSHD CPSE HLNG KSIH DIEN VLLK PENL YN
Gene ID:10203
Uniprot:Q16602
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:52kDa
Observed MW:43kDa
Synonyms:CALCRL, CGRPR, CRLR
Background:
UniProt Protein Function:CALCRL: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: endoplasmic reticulum; endosome; integral to plasma membrane; lysosome; plasma membrane

Molecular Function:adrenomedullin receptor activity; G-protein coupled receptor activity; protein binding; protein transporter activity

Biological Process: angiogenesis; calcium ion transport; cAMP biosynthetic process; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cAMP biosynthetic process; protein transport; receptor internalization

UniProt Code:Q16602
NCBI GenInfo Identifier:226693507
NCBI Gene ID:10203
NCBI Accession:Q16602.2
UniProt Secondary Accession:Q16602,Q53S02, Q53TS5, A8K6G5, A8KAD3,
UniProt Related Accession:Q16602
Molecular Weight:52,929 Da
NCBI Full Name:Calcitonin gene-related peptide type 1 receptor
NCBI Synonym Full Names:calcitonin receptor like receptor
NCBI Official Symbol:CALCRL  
NCBI Official Synonym Symbols:CRLR; CGRPR  
NCBI Protein Information:calcitonin gene-related peptide type 1 receptor
UniProt Protein Name:Calcitonin gene-related peptide type 1 receptor
UniProt Synonym Protein Names:Calcitonin receptor-like receptor
Protein Family:Calcitonin gene-related peptide type 1 receptor
UniProt Gene Name:CALCRL  
UniProt Entry Name:CALRL_HUMAN
Anti-CALCRL Polyclonal Antibody (CAB8533)Western blot analysis of extracts of various cell lines, using CALCRL antibody (CAB8533) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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