Cell Biology Antibodies 12
Anti-CALCRL Antibody (CAB8533)
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- SKU:
- CAB8533
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CALCRL Antibody |
| Antibody SKU: | CAB8533 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 392-461 of human CALCRL (NP_005786.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, MCF7, Mouse kidney, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 392-461 of human CALCRL (NP_005786.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QAIL RRNW NQYK IQFG NSFS NSEA LRSA SYTV STIS DGPG YSHD CPSE HLNG KSIH DIEN VLLK PENL YN |
| Gene ID: | 10203 |
| Uniprot: | Q16602 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 52kDa |
| Observed MW: | 43kDa |
| Synonyms: | CALCRL, CGRPR, CRLR |
| Background: |
| UniProt Protein Function: | CALCRL: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR; Cell cycle regulation Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: endoplasmic reticulum; endosome; integral to plasma membrane; lysosome; plasma membrane Molecular Function:adrenomedullin receptor activity; G-protein coupled receptor activity; protein binding; protein transporter activity Biological Process: angiogenesis; calcium ion transport; cAMP biosynthetic process; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cAMP biosynthetic process; protein transport; receptor internalization |
| UniProt Code: | Q16602 |
| NCBI GenInfo Identifier: | 226693507 |
| NCBI Gene ID: | 10203 |
| NCBI Accession: | Q16602.2 |
| UniProt Secondary Accession: | Q16602,Q53S02, Q53TS5, A8K6G5, A8KAD3, |
| UniProt Related Accession: | Q16602 |
| Molecular Weight: | 52,929 Da |
| NCBI Full Name: | Calcitonin gene-related peptide type 1 receptor |
| NCBI Synonym Full Names: | calcitonin receptor like receptor |
| NCBI Official Symbol: | CALCRL |
| NCBI Official Synonym Symbols: | CRLR; CGRPR |
| NCBI Protein Information: | calcitonin gene-related peptide type 1 receptor |
| UniProt Protein Name: | Calcitonin gene-related peptide type 1 receptor |
| UniProt Synonym Protein Names: | Calcitonin receptor-like receptor |
| Protein Family: | Calcitonin gene-related peptide type 1 receptor |
| UniProt Gene Name: | CALCRL |
| UniProt Entry Name: | CALRL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CALCRL antibody (CAB8533) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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