Cell Biology Antibodies 4
Anti-CALCA Antibody (CAB13957)
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- SKU:
- CAB13957
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CALCA Antibody |
| Antibody SKU: | CAB13957 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human CALCA (NP_001029124.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human CALCA (NP_001029124.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGFQ KFSP FLAL SILV LLQA GSLH AAPF RSAL ESSP ADPA TLSE DEAR LLLA ALVQ DYVQ MKAS ELEQ EQER EGSS LDSP RSKR CGNL STCM LGTY TQDF NKFH TFPQ TAIG VGAP GKKR DMSS DLER DHRP HVSM PQNA N |
| Gene ID: | 796 |
| Uniprot: | P01258/P06881 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa/15kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CALCA, CALC1, CGRP, CGRP-I, CGRP1, CT, KC, PCT |
| Background: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular region; extracellular space Molecular Function:calcitonin receptor binding; identical protein binding; protein binding Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity |
| NCBI Summary: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014] |
| UniProt Code: | P01258 |
| NCBI GenInfo Identifier: | 322510018 |
| NCBI Gene ID: | 796 |
| NCBI Accession: | P01258.2 |
| UniProt Secondary Accession: | P01258,Q13935, Q13937, Q52LX7, B7ZL39, |
| UniProt Related Accession: | P01258,P06881 |
| Molecular Weight: | 38.6kDa |
| NCBI Full Name: | Calcitonin |
| NCBI Synonym Full Names: | calcitonin related polypeptide alpha |
| NCBI Official Symbol: | CALCA |
| NCBI Official Synonym Symbols: | CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I |
| NCBI Protein Information: | calcitonin; calcitonin gene-related peptide 1 |
| UniProt Protein Name: | Calcitonin |
| UniProt Synonym Protein Names: | CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP |
| UniProt Gene Name: | CALCA |
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