Cell Biology Antibodies 17
Anti-Calbindin Antibody (CAB4284)
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- SKU:
- CAB4284
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Calbindin Antibody |
| Antibody SKU: | CAB4284 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Calbindin |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat kidney |
| Immunogen: | A synthesized peptide derived from human Calbindin |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 793 |
| Uniprot: | P05937 |
| Cellular Location: | |
| Calculated MW: | 30kDa |
| Observed MW: | 28KDa |
| Synonyms: | CALB, D-28K |
| Background: | The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015] |
| UniProt Protein Function: | CALB1: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Interacts with RANBP9. Belongs to the calbindin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 8q21.3 Cellular Component: cell soma; axon; dendrite; synapse; nucleus; cytosol Molecular Function:vitamin D binding; protein binding; zinc ion binding; calcium ion binding Biological Process: cytosolic calcium ion homeostasis; long-term memory; short-term memory; regulation of synaptic plasticity; locomotory behavior |
| NCBI Summary: | Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05937 |
| NCBI GenInfo Identifier: | 115394 |
| NCBI Gene ID: | 793 |
| NCBI Accession: | P05937.2 |
| UniProt Secondary Accession: | P05937,B2R696, B7Z9J4, |
| UniProt Related Accession: | P05937 |
| Molecular Weight: | 23,609 Da |
| NCBI Full Name: | Calbindin |
| NCBI Synonym Full Names: | calbindin 1, 28kDa |
| NCBI Official Symbol: | CALB1 |
| NCBI Official Synonym Symbols: | CALB |
| NCBI Protein Information: | calbindin; D-28K; calbindin D28; RTVL-H protein; calbindin 1, (28kD); vitamin D-dependent calcium-binding protein, avian-type |
| UniProt Protein Name: | Calbindin |
| UniProt Synonym Protein Names: | Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type |
| Protein Family: | Calbindin |
| UniProt Gene Name: | CALB1 |
| UniProt Entry Name: | CALB1_HUMAN |
 | Western blot - Calbindin Rabbit mAb (CAB4284) |
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