Cell Biology Antibodies 1
Anti-CALB1 Antibody (CAB0802)
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- SKU:
- CAB0802
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CALB1 Antibody |
| Antibody SKU: | CAB0802 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human CALB1 (NP_004920.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse eye, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human CALB1 (NP_004920.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAES HLQS SLIT ASQF FEIW LHFD ADGS GYLE GKEL QNLI QELQ QARK KAGL ELSP EMKT FVDQ YGQR DDGK IGIV ELAH VLPT EENF LLLF RCQQ LKSC EEFM KTWR KYDT DHSG FIET EELK NFLK DLLE KANK TVDD TKLA EYTD LMLK LFDS NNDG KLEL TEMA RLLP VQEN FLLK FQGI KMCG KEFN KAFE LYDQ DGNG YIDE NELD ALLK DLCE KNKQ DLDI NNIT TYKK NIMA LSDG GKLY RTDL ALIL CAGD N |
| Gene ID: | 793 |
| Uniprot: | P05937 |
| Cellular Location: | |
| Calculated MW: | 23kDa/30kDa |
| Observed MW: | 30kDa |
| Synonyms: | CALB1, CALB, D-28K, calbindin, Calbindin |
| Background: | The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. |
| UniProt Protein Function: | CALB1: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Interacts with RANBP9. Belongs to the calbindin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 8q21.3 Cellular Component: cell soma; axon; dendrite; synapse; nucleus; cytosol Molecular Function:vitamin D binding; protein binding; zinc ion binding; calcium ion binding Biological Process: cytosolic calcium ion homeostasis; long-term memory; short-term memory; regulation of synaptic plasticity; locomotory behavior |
| NCBI Summary: | Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05937 |
| NCBI GenInfo Identifier: | 115394 |
| NCBI Gene ID: | 793 |
| NCBI Accession: | P05937.2 |
| UniProt Secondary Accession: | P05937,B2R696, B7Z9J4, |
| UniProt Related Accession: | P05937 |
| Molecular Weight: | 23,609 Da |
| NCBI Full Name: | Calbindin |
| NCBI Synonym Full Names: | calbindin 1, 28kDa |
| NCBI Official Symbol: | CALB1 |
| NCBI Official Synonym Symbols: | CALB |
| NCBI Protein Information: | calbindin; D-28K; calbindin D28; RTVL-H protein; calbindin 1, (28kD); vitamin D-dependent calcium-binding protein, avian-type |
| UniProt Protein Name: | Calbindin |
| UniProt Synonym Protein Names: | Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type |
| Protein Family: | Calbindin |
| UniProt Gene Name: | CALB1 |
| UniProt Entry Name: | CALB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CALB1 antibody (CAB0802) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using CALB1 antibody (CAB0802) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using CALB1 antibody (CAB0802) at dilution of 1:100 (40x lens). |
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