Cell Biology Antibodies 4
Anti-CADPS2 Antibody (CAB13821)
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- SKU:
- CAB13821
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CADPS2 Antibody |
| Antibody SKU: | CAB13821 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CADPS2 (NP_001009571.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-431, SGC-7901 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CADPS2 (NP_001009571.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLDP SSSE EESD EGLE EESR DVLV AAGS SQRA PPAP TREG RRDA PGRA GGGG AARS VSPS PSVL SEGR DEPQ RQLD DEQE |
| Gene ID: | 93664 |
| Uniprot: | Q86UW7 |
| Cellular Location: | Cell junction, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, synapse |
| Calculated MW: | 142kDa/143kDa/147kDa |
| Observed MW: | 148kDa |
| Synonyms: | CADPS2, CAPS2 |
| Background: | This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q31.3 Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction Molecular Function:metal ion binding; lipid binding Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis |
| NCBI Summary: | This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q86UW7 |
| NCBI GenInfo Identifier: | 148839294 |
| NCBI Gene ID: | 93664 |
| NCBI Accession: | NP_060424 |
| UniProt Related Accession: | Q86UW7 |
| Molecular Weight: | |
| NCBI Full Name: | calcium-dependent secretion activator 2 isoform a |
| NCBI Synonym Full Names: | calcium dependent secretion activator 2 |
| NCBI Official Symbol: | CADPS2 |
| NCBI Official Synonym Symbols: | CAPS2 |
| NCBI Protein Information: | calcium-dependent secretion activator 2 |
| UniProt Protein Name: | Calcium-dependent secretion activator 2 |
| UniProt Synonym Protein Names: | Calcium-dependent activator protein for secretion 2; CAPS-2 |
| Protein Family: | Calcyphosin |
| UniProt Gene Name: | CADPS2 |
| UniProt Entry Name: | CAPS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CADPS2 antibody (CAB13821) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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