Cell Biology Antibodies 14

Anti-CADPS Antibody (CAB17026)

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SKU:
CAB17026
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CADPS Antibody
Antibody SKU:CAB17026
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1020-1100 of human CADPS (NP_899630.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1020-1100 of human CADPS (NP_899630.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASD MIES CVKR TRIA FEVK LQKT SRST DFRV PQSI CTMF NVMV DAKA QSTK LCSM EMGQ EHQY HSKI DELI EETV KEMI T
Gene ID:8618
Uniprot:Q9ULU8
Cellular Location:
Calculated MW:50kDa/144kDa/148kDa/152kDa/153kDa
Observed MW:Refer to figures
Anti-CADPS Antibody (CAB17026)Immunohistochemistry - CADPS Polyclonal Antibody (CAB17026)
Synonyms:CADPS, CADPS1, CAPS, CAPS1, UNC-31
Background:This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
UniProt Protein Function:CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 3p14.2

Cellular Component: cytoplasmic vesicle membrane; synapse; cell junction; cytosol

Molecular Function:protein binding; metal ion binding; lipid binding; protein kinase binding

Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming

NCBI Summary:This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
UniProt Code:Q9ULU8
NCBI GenInfo Identifier:34452715
NCBI Gene ID:8618
NCBI Accession:NP_003707.2
UniProt Secondary Accession:Q9ULU8,Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2 A6NF60,
UniProt Related Accession:Q9ULU8
Molecular Weight:50,236 Da
NCBI Full Name:calcium-dependent secretion activator 1 isoform 1
NCBI Synonym Full Names:Ca++-dependent secretion activator
NCBI Official Symbol:CADPS  
NCBI Official Synonym Symbols:CAPS; CAPS1; CADPS1  
NCBI Protein Information:calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent activator protein for secretion; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; calcium-dependent activator protein for secretion 1
UniProt Protein Name:Calcium-dependent secretion activator 1
UniProt Synonym Protein Names:Calcium-dependent activator protein for secretion 1; CAPS-1
Protein Family:Calcyphosin
UniProt Gene Name:CADPS  
UniProt Entry Name:CAPS1_HUMAN
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