Antibody Name:	CDH6 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8109
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human CDH6 (NP_004923.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse kidney, Mouse brain, Rat kidney, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human CDH6 (NP_004923.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MRTY RYFL LLFW VGQP YPTL STPL SKRT SGFP AKKR ALEL SGNS KNEL NRSK RSWM WNQF FLLE EYTG SDYQ YVGK LHSD QDRG DGSL KYIL SGDG AGDL FIIN ENTG DIQA TKRL DREE KPVY ILRA QAIN RRTG RPVE PESE FIIK IHDI NDNE PIFT KEVY TATV PEMS DVGT FVVQ VTAT DADD PTYG NSAK VVYS ILQG QPYF SVES ETGI IKTA LLNM DREN REQY QVVI QAKD MGGQ MGGL SG
Gene ID:	1004
Uniprot:	P55285
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	73kDa/88kDa
Observed MW:	100kDa

Synonyms:

CDH6, CAD6, KCAD

Background:

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

UniProt Protein Function:	CDH6: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5p13.3 Cellular Component: plasma membrane; integral to membrane Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion; cell adhesion
NCBI Summary:	This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
UniProt Code:	P55285
NCBI GenInfo Identifier:	1705545
NCBI Gene ID:	1004
NCBI Accession:	P55285.1
UniProt Secondary Accession:	P55285,Q9BWS0, A8K5H5,
UniProt Related Accession:	P55285
Molecular Weight:	73,864 Da
NCBI Full Name:	Cadherin-6
NCBI Synonym Full Names:	cadherin 6, type 2, K-cadherin (fetal kidney)
NCBI Official Symbol:	CDH6
NCBI Official Synonym Symbols:	CAD6; KCAD
NCBI Protein Information:	cadherin-6
UniProt Protein Name:	Cadherin-6
UniProt Synonym Protein Names:	Kidney cadherin; K-cadherin
Protein Family:	Cadherin
UniProt Gene Name:	CDH6
UniProt Entry Name:	CADH6_HUMAN

	Western blot analysis of extracts of various cell lines, using CDH6 antibody (CAB8109) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat kidney using CDH6 antibody (CAB8109) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using CDH6 antibody (CAB8109) at dilution of 1:100 (40x lens).