Cell Biology Antibodies 11
Anti-Cadherin-11 Antibody (CAB8110)
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- SKU:
- CAB8110
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | CDH11 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8110 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 637-796 of human CDH11 (NP_001788.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, HT-29, SKOV3, Mouse lung, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 637-796 of human CDH11 (NP_001788.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FVTL RRQK KEPL IVFE EEDV RENI ITYD DEGG GEED TEAF DIAT LQNP DGIN GFIP RKDI KPEY QYMP RPGL RPAP NSVD VDDF INTR IQEA DNDP TAPP YDSI QIYG YEGR GSVA GSLS SLES ATTD SDLD YDYL QNWG PRFK KLAD LYGS KDTF DDDS |
| Gene ID: | 1009 |
| Uniprot: | P55287 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 76kDa/87kDa |
| Observed MW: | 120kDa |
| Synonyms: | CDH11, CAD11, CDHOB, OB, OSF-4 |
| Background: | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. |
| UniProt Protein Function: | CDH11: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with PCDH8. Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q21 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; ossification; corticospinal tract morphogenesis; homophilic cell adhesion; cell adhesion; skeletal development |
| UniProt Code: | P55287 |
| NCBI GenInfo Identifier: | 16306532 |
| NCBI Gene ID: | 1009 |
| NCBI Accession: | NP_001788 |
| UniProt Secondary Accession: | P55287,Q15065, Q15066, Q9UQ93, Q9UQ94, A8K5D6, A8MZC8 B7WP28, |
| UniProt Related Accession: | P55287 |
| Molecular Weight: | 76,457 Da |
| NCBI Full Name: | cadherin-11 preproprotein |
| NCBI Synonym Full Names: | cadherin 11, type 2, OB-cadherin (osteoblast) |
| NCBI Official Symbol: | CDH11 |
| NCBI Official Synonym Symbols: | OB; CAD11; CDHOB; OSF-4 |
| NCBI Protein Information: | cadherin-11 |
| UniProt Protein Name: | Cadherin-11 |
| UniProt Synonym Protein Names: | OSF-4; Osteoblast cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH11 |
| UniProt Entry Name: | CAD11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH11 antibody (CAB8110) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CDH11 antibody (CAB8110) at dilution of 1:100 (40x lens). |
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