Name: Anti-CACNA1D Antibody (CAB16785)
Brand: Cell Biology Antibodies 14
SKU: CAB16785
Availability: OutOfStock

Antibody Name:	Anti-CACNA1D Antibody
Antibody SKU:	CAB16785
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1882-2181 of human CACNA1D (NP_000711.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Rat
Positive Samples:	Rat kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1882-2181 of human CACNA1D (NP_000711.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RQNY GYYS RYPG RNID SERP RGYH HPQG FLED DDSP VCYD SRRS PRRR LLPP TPAS HRRS SFNF ECLR RQSS QEEV PSSP IFPH RTAL PLHL MQQQ IMAV AGLD SSKA QKYS PSHS TRSW ATPP ATPP YRDW TPCY TPLI QVEQ SEAL DQVN GSLP SLHR SSWY TDEP DISY RTFT PASL TVPS SFRN KNSD KQRS ADSL VEAV LISE GLGR YARD PKFV SATK HEIA DACD LTID EMES AAST LLNG NVRP RANG DVGP LSHR QDYE LQDF GPGY SDEE PDPG RDEE DLAD EMIC ITTL
Gene ID:	776
Uniprot:	Q01668
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	187kDa/242kDa/245kDa/247kDa
Observed MW:	245kDa

Western blot - CACNA1D Rabbit pAb (CAB16785)

Synonyms:

CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD

Background:

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	CACNA1D: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: plasma membrane; voltage-gated calcium channel complex; Z disc Molecular Function:voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity; ankyrin binding; alpha-actinin binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; axon guidance; sensory perception of sound; calcium ion transport; energy reserve metabolic process; positive regulation of calcium ion transport; regulation of insulin secretion Disease: Primary Aldosteronism, Seizures, And Neurologic Abnormalities; Sinoatrial Node Dysfunction And Deafness
NCBI Summary:	Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Code:	Q01668
NCBI GenInfo Identifier:	116241275
NCBI Gene ID:	776
NCBI Accession:	Q01668.2
UniProt Related Accession:	Q01668
Molecular Weight:
NCBI Full Name:	Voltage-dependent L-type calcium channel subunit alpha-1D
NCBI Synonym Full Names:	calcium voltage-gated channel subunit alpha1 D
NCBI Official Symbol:	CACNA1D
NCBI Official Synonym Symbols:	CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2
NCBI Protein Information:	voltage-dependent L-type calcium channel subunit alpha-1D
UniProt Protein Name:	Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt Synonym Protein Names:	Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3
UniProt Gene Name:	CACNA1D
UniProt Entry Name:	CAC1D_HUMAN