Cell Biology Antibodies 18

Anti-CABP1 Antibody (CAB18406)

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SKU:
CAB18406
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CABP1 Antibody
Antibody SKU:CAB18406
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CABP1.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant protein of human CABP1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9478
Uniprot:Q9NZU7
Cellular Location:
Calculated MW:
Observed MW:25kDa
Anti-CABP1 Antibody (CAB18406)Western blot - CABP1 Rabbit pAb (CAB18406)
Synonyms:CALBRAIN, HCALB_BR, CABP1
Background:
UniProt Protein Function:CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Calcium-binding; Inhibitor; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space; internal side of plasma membrane; protein complex; postsynaptic density; dendrite; cell cortex; cytosol; Golgi membrane; postsynaptic membrane; cytoskeleton; cell soma; perinuclear region of cytoplasm; plasma membrane; nucleus; cell junction

Molecular Function:enzyme inhibitor activity; protein domain specific binding; protein binding; protein homodimerization activity; nuclear localization sequence binding; type 3 metabotropic glutamate receptor binding; calcium ion binding; calcium-dependent protein binding

Biological Process: negative regulation of catalytic activity; negative regulation of protein import into nucleus

NCBI Summary:Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]
UniProt Code:Q9NZU7
NCBI GenInfo Identifier:334302962
NCBI Gene ID:9478
NCBI Accession:Q9NZU7.5
UniProt Secondary Accession:Q9NZU7,O95663, Q8N6H5, Q9NZU8,
UniProt Related Accession:Q9NZU7
Molecular Weight:8,139 Da
NCBI Full Name:Calcium-binding protein 1
NCBI Synonym Full Names:calcium binding protein 1
NCBI Official Symbol:CABP1  
NCBI Official Synonym Symbols:CALBRAIN; HCALB_BR  
NCBI Protein Information:calcium-binding protein 1; caldendrin; calcium binding protein 5
UniProt Protein Name:Calcium-binding protein 1
UniProt Synonym Protein Names:Calbrain; Caldendrin
Protein Family:Calcium-binding protein
UniProt Gene Name:CABP1  
UniProt Entry Name:CABP1_HUMAN
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