Cell Biology Antibodies 18
Anti-CABP1 Antibody (CAB18406)
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- SKU:
- CAB18406
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CABP1 Antibody |
| Antibody SKU: | CAB18406 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CABP1. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant protein of human CABP1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9478 |
| Uniprot: | Q9NZU7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 25kDa |
 | Western blot - CABP1 Rabbit pAb (CAB18406) |
| Synonyms: | CALBRAIN, HCALB_BR, CABP1 |
| Background: |
| UniProt Protein Function: | CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Inhibitor; Adaptor/scaffold Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: extracellular space; internal side of plasma membrane; protein complex; postsynaptic density; dendrite; cell cortex; cytosol; Golgi membrane; postsynaptic membrane; cytoskeleton; cell soma; perinuclear region of cytoplasm; plasma membrane; nucleus; cell junction Molecular Function:enzyme inhibitor activity; protein domain specific binding; protein binding; protein homodimerization activity; nuclear localization sequence binding; type 3 metabotropic glutamate receptor binding; calcium ion binding; calcium-dependent protein binding Biological Process: negative regulation of catalytic activity; negative regulation of protein import into nucleus |
| NCBI Summary: | Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q9NZU7 |
| NCBI GenInfo Identifier: | 334302962 |
| NCBI Gene ID: | 9478 |
| NCBI Accession: | Q9NZU7.5 |
| UniProt Secondary Accession: | Q9NZU7,O95663, Q8N6H5, Q9NZU8, |
| UniProt Related Accession: | Q9NZU7 |
| Molecular Weight: | 8,139 Da |
| NCBI Full Name: | Calcium-binding protein 1 |
| NCBI Synonym Full Names: | calcium binding protein 1 |
| NCBI Official Symbol: | CABP1 |
| NCBI Official Synonym Symbols: | CALBRAIN; HCALB_BR |
| NCBI Protein Information: | calcium-binding protein 1; caldendrin; calcium binding protein 5 |
| UniProt Protein Name: | Calcium-binding protein 1 |
| UniProt Synonym Protein Names: | Calbrain; Caldendrin |
| Protein Family: | Calcium-binding protein |
| UniProt Gene Name: | CABP1 |
| UniProt Entry Name: | CABP1_HUMAN |
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