Cell Biology Antibodies 1
Anti-CA12 Antibody (CAB10187)
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- SKU:
- CAB10187
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CA12 Antibody |
| Antibody SKU: | CAB10187 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-301 of human CA12 (NP_001209.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-301 of human CA12 (NP_001209.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APVN GSKW TYFG PDGE NSWS KKYP SCGG LLQS PIDL HSDI LQYD ASLT PLEF QGYN LSAN KQFL LTNN GHSV KLNL PSDM HIQG LQSR YSAT QLHL HWGN PNDP HGSE HTVS GQHF AAEL HIVH YNSD LYPD ASTA SNKS EGLA VLAV LIEM GSFN PSYD KIFS HLQH VKYK GQEA FVPG FNIE ELLP ERTA EYYR YRGS LTTP PCNP TVLW TVFR NPVQ ISQE QLLA LETA LYCT HMDD PSPR EMIN NFRQ VQKF DERL VYTS FSQV QVCT AAGL S |
| Gene ID: | 771 |
| Uniprot: | O43570 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 38kDa/39kDa |
| Observed MW: | 50kDa |
| Synonyms: | CA12, CA-XII, CAXII, HsT18816, T18816 |
| Background: | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. |
| UniProt Protein Function: | Reversible hydration of carbon dioxide. |
| NCBI Summary: | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014] |
| UniProt Code: | O43570 |
| NCBI GenInfo Identifier: | 5915866 |
| NCBI Gene ID: | 771 |
| NCBI Accession: | O43570.1 |
| UniProt Secondary Accession: | O43570,Q53YE5, Q9BWG2, B2RE24, |
| UniProt Related Accession: | O43570 |
| Molecular Weight: | 38,408 Da |
| NCBI Full Name: | Carbonic anhydrase 12 |
| NCBI Synonym Full Names: | carbonic anhydrase 12 |
| NCBI Official Symbol: | CA12 |
| NCBI Official Synonym Symbols: | CAXII; CA-XII; T18816; HsT18816 |
| NCBI Protein Information: | carbonic anhydrase 12 |
| UniProt Protein Name: | Carbonic anhydrase 12 |
| UniProt Synonym Protein Names: | Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3 |
| Protein Family: | Carbonic anhydrase |
| UniProt Gene Name: | CA12 |
| UniProt Entry Name: | CAH12_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using CA12 antibody (CAB10187) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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