Cell Death Antibodies 2

Anti-C8orf4 Antibody (CAB6241)

(No reviews yet) Write a Review
SKU:
CAB6241
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-C8orf4 Antibody
Antibody SKU:CAB6241
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKAK RSHQ AIIM STSL RVSP SIHG YHFD TASR KKAV GNIF ENTD QESL ERLF RNSG DKKA EERA KIIF AIDQ DVEE KTRA LMAL KKRT KDKL FQFL KLRK YSIK VH
Gene ID:56892
Uniprot:Q9NR00
Cellular Location:Cytoplasm, Nucleus, Nucleus speckle, nucleolus
Calculated MW:12kDa
Observed MW:Refer to figures
Synonyms:C8orf4, TC-1, TC1
Background:This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
UniProt Protein Function:C8orf4: May decrease apoptosis.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 8p11.2

Biological Process: apoptosis

NCBI Summary:This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
UniProt Code:Q9NR00
NCBI GenInfo Identifier:296434443
NCBI Gene ID:56892
NCBI Accession:Q9NR00.2
UniProt Related Accession:Q9NR00
Molecular Weight:106
NCBI Full Name:Uncharacterized protein C8orf4
NCBI Synonym Full Names:chromosome 8 open reading frame 4
NCBI Official Symbol:C8orf4  
NCBI Official Synonym Symbols:TC1; TC-1  
NCBI Protein Information:uncharacterized protein C8orf4; human thyroid cancer 1; thyroid cancer protein 1
UniProt Protein Name:Uncharacterized protein C8orf4
UniProt Synonym Protein Names:Thyroid cancer protein 1; TC-1
Protein Family:Protein
UniProt Gene Name:C8orf4  
UniProt Entry Name:CH004_HUMAN
Anti-C8orf4 Antibody (CAB6241)Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens).
Anti-C8orf4 Antibody (CAB6241)Immunohistochemistry of paraffin-embedded human stomach using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens).
Anti-C8orf4 Antibody (CAB6241)Immunohistochemistry of paraffin-embedded mouse lung using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens).
View AllClose

0 Reviews

View AllClose

Related Products