Cell Biology Antibodies 13
Anti-C8G Antibody (CAB17297)
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- SKU:
- CAB17297
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-C8G Antibody |
| Antibody SKU: | CAB17297 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human C8G (NP_000597.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human C8G (NP_000597.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLPP GTAT LLTL LLAA GSLG QKPQ RPRR PASP ISTI QPKA NFDA QQFA GTWL LVAV GSAC RFLQ EQGH RAEA TTLH VAPQ GTAM AVST FRKL DGIC WQVR QLYG DTGV LGRF LLQA RDAR GAVH VVVA ETDY QSFA VLYL ERAG QLSV KLYA RSLP VSDS VLSG FEQR VQEA HLTE DQIF YFPK YGFC EAAD QFHV LDEV RR |
| Gene ID: | 733 |
| Uniprot: | P07360 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | C8C, C8G |
| Background: | The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011] |
| UniProt Protein Function: | C8G: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Belongs to the calycin superfamily. Lipocalin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: membrane attack complex; extracellular region Molecular Function:complement binding; protein complex binding; retinol binding Biological Process: cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011] |
| UniProt Code: | P07360 |
| NCBI GenInfo Identifier: | 166197660 |
| NCBI Gene ID: | 733 |
| NCBI Accession: | NP_000597.2 |
| UniProt Secondary Accession: | P07360,Q14CT8, Q14CU0, Q5SQ07, |
| UniProt Related Accession: | P07360 |
| Molecular Weight: | 22,277 Da |
| NCBI Full Name: | complement component C8 gamma chain |
| NCBI Synonym Full Names: | complement component 8, gamma polypeptide |
| NCBI Official Symbol: | C8G |
| NCBI Official Synonym Symbols: | C8C |
| NCBI Protein Information: | complement component C8 gamma chain |
| UniProt Protein Name: | Complement component C8 gamma chain |
| Protein Family: | Complement component |
| UniProt Gene Name: | C8G |
| UniProt Entry Name: | CO8G_HUMAN |
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