Cell Biology Antibodies 1
Anti-C6orf25 Antibody (CAB10154)
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- SKU:
- CAB10154
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-C6orf25 Antibody |
| Antibody SKU: | CAB10154 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-142 of human C6orf25 (NP_612121.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Jurkat, SW620, Mouse small intestine, Mouse pancreas, Rat pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-142 of human C6orf25 (NP_612121.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NPGA SLDG RPGD RVNL SCGG VSHP IRWV WAPS FPAC KGLS KGRR PILW ASSS GTPT VPPL QPFV GRLR SLDS GIRR LELL LSAG DSGT FFCK GRHE DESR TVLH VLGD RTYC KAPG PTHG SVYP Q |
| Gene ID: | 80739 |
| Uniprot: | O95866 |
| Cellular Location: | Cell membrane, Endoplasmic reticulum, Golgi apparatus, Golgi apparatus, Single-pass type I membrane protein |
| Calculated MW: | 20kDa/21kDa/23kDa/24kDa/25kDa/26kDa |
| Observed MW: | 26kDa |
| Synonyms: | MPIG6B, C6orf25, G6b, G6b-B, NG31, THAMY |
| Background: | This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | G6B: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily; Receptor, misc. Chromosomal Location of Human Ortholog: 6p21.33 Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to membrane; plasma membrane Molecular Function:heparin binding Biological Process: integrin-mediated signaling pathway; platelet formation; blood coagulation |
| NCBI Summary: | This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95866 |
| NCBI GenInfo Identifier: | 19913373 |
| NCBI Gene ID: | 80739 |
| NCBI Accession: | NP_079536.2 |
| UniProt Secondary Accession: | O95866,Q14CK2, A2BEZ1, A2BEZ2, A2BEZ3, A2BEZ4, A2BEZ5 B0UXC4, B0UXC7, B0UXC8, B0V024, B0V026, |
| UniProt Related Accession: | O95866 |
| Molecular Weight: | 26,163 Da |
| NCBI Full Name: | protein G6b isoform G6b-A |
| NCBI Synonym Full Names: | chromosome 6 open reading frame 25 |
| NCBI Official Symbol: | C6orf25 |
| NCBI Official Synonym Symbols: | G6b; NG31 |
| NCBI Protein Information: | protein G6b; immunoglobulin receptor |
| UniProt Protein Name: | Protein G6b |
| Protein Family: | Protein |
| UniProt Gene Name: | G6B |
| UniProt Entry Name: | G6B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C6orf25 antibody (CAB10154) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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