Immunology Antibodies 1

Anti-C6 Antibody (CAB10170)

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SKU:
CAB10170
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-C6 Antibody
Antibody SKU:CAB10170
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human C6 (NP_000056.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human C6 (NP_000056.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CFCD HYAW TQWT SCSK TCNS GTQS RHRQ IVVD KYYQ ENFC EQIC SKQE TREC NWQR CPIN CLLG DFGP WSDC DPCI EKQS KVRS VLRP SQFG GQPC TAPL VAFQ PCIP SKLC KIEE ADCK NKFR CDSG RCIA RKLE CNGE NDCG DNSD ERDC GRTK AVCT RKYN PIPS VQLM GNGF HFLA GEPR GEVL DNSF TGGI CKTV KSSR TSNP YRVP ANLE NVGF EVQT AEDD LKTD FYKD LTS
Gene ID:729
Uniprot:P13671
Cellular Location:Secreted
Calculated MW:104kDa
Observed MW:110kDa
Synonyms:C6
Background:This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.
UniProt Protein Function:C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: extracellular region; membrane attack complex

Molecular Function:protein binding

Biological Process: complement activation; regulation of complement activation

Disease: Complement Component 6 Deficiency

NCBI Summary:This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
UniProt Code:P13671
NCBI GenInfo Identifier:146345396
NCBI Gene ID:729
NCBI Accession:P13671.3
UniProt Related Accession:P13671
Molecular Weight:104,786 Da
NCBI Full Name:Complement component C6
NCBI Synonym Full Names:complement C6
NCBI Official Symbol:C6  
NCBI Protein Information:complement component C6
UniProt Protein Name:Complement component C6
Protein Family:Complement component
UniProt Gene Name:C6  
Anti-C6 Antibody (CAB10170)Western blot analysis of extracts of various cell lines, using C6 antibody (CAB10170) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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