Immunology Antibodies 2
Anti-C4BPA Antibody (CAB7648)
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- SKU:
- CAB7648
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C4BPA Antibody |
| Antibody SKU: | CAB7648 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human C4BPA (NP_000706.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HepG2, HL-60 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human C4BPA (NP_000706.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QYVE PENV TIQC DSGY GVVG PQSI TCSG NRTW YPEV PKCE WETP EGCE QVLT GKRL MQCL PNPE DVKM ALEV YKLS LEIE QLEL QRDS ARQS TLDK EL |
| Gene ID: | 722 |
| Uniprot: | P04003 |
| Cellular Location: | Secreted |
| Calculated MW: | 67kDa |
| Observed MW: | 67kDa |
| Synonyms: | C4BPA, C4BP, PRP |
| Background: | This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. |
| UniProt Protein Function: | C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1q32 Cellular Component: extracellular space; extracellular region; plasma membrane Molecular Function:protein binding Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; complement activation, classical pathway |
| NCBI Summary: | This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04003 |
| NCBI GenInfo Identifier: | 18490166 |
| NCBI Gene ID: | 722 |
| NCBI Accession: | AAH22312.1 |
| UniProt Secondary Accession: | P04003,Q5VVQ8, |
| UniProt Related Accession: | P04003 |
| Molecular Weight: | 67,033 Da |
| NCBI Full Name: | Complement component 4 binding protein, alpha |
| NCBI Synonym Full Names: | complement component 4 binding protein, alpha |
| NCBI Official Symbol: | C4BPA |
| NCBI Official Synonym Symbols: | PRP; C4BP |
| NCBI Protein Information: | C4b-binding protein alpha chain; proline-rich protein |
| UniProt Protein Name: | C4b-binding protein alpha chain |
| UniProt Synonym Protein Names: | Proline-rich protein; PRP |
| Protein Family: | Complement C4 |
| UniProt Gene Name: | C4BPA |
| UniProt Entry Name: | C4BPA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C4BPA antibody (CAB7648) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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