Immunology Antibodies 1
Anti-C2 Antibody (CAB10186)
- SKU:
- CAB10186
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C2 Antibody |
| Antibody SKU: | CAB10186 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 453-752 of human C2 (NP_000054.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, 293T, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 453-752 of human C2 (NP_000054.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LDVS KLTD TICG VGNM SANA SDQE RTPW HVTI KPKS QETC RGAL ISDQ WVLT AAHC FRDG NDHS LWRV NVGD PKSQ WGKE FLIE KAVI SPGF DVFA KKNQ GILE FYGD DIAL LKLA QKVK MSTH ARPI CLPC TMEA NLAL RRPQ GSTC RDHE NELL NKQS VPAH FVAL NGSK LNIN LKMG VEWT SCAE VVSQ EKTM FPNL TDVR EVVT DQFL CSGT QEDE SPCK GESG GAVF LERR FRFF QVGL VSWG LYNP CLGS ADKN SRKR APRS KVPP PRDF HINL FRMQ PWLR QHLG DVLN FLPL |
| Gene ID: | 717 |
| Uniprot: | P06681 |
| Cellular Location: | Secreted |
| Calculated MW: | 60kDa/69kDa/83kDa |
| Observed MW: | 70kDa/110kDa |
| Synonyms: | C2, ARMD14, CO2 |
| Background: | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. |
| UniProt Protein Function: | Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. |
| NCBI Summary: | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009] |
| UniProt Code: | P06681 |
| NCBI GenInfo Identifier: | 3915642 |
| NCBI Gene ID: | 717 |
| NCBI Accession: | P06681.2 |
| UniProt Secondary Accession: | P06681,O19694, Q13904, B4DPF3, B4DV20, E9PFN7, |
| UniProt Related Accession: | P06681 |
| Molecular Weight: | 83kDa |
| NCBI Full Name: | Complement C2 |
| NCBI Synonym Full Names: | complement C2 |
| NCBI Official Symbol: | C2 |
| NCBI Official Synonym Symbols: | CO2; ARMD14 |
| NCBI Protein Information: | complement C2 |
| UniProt Protein Name: | Complement C2 |
| UniProt Synonym Protein Names: | C3/C5 convertase |
| Protein Family: | Complement C2 |
| UniProt Gene Name: | C2 |
 | Western blot analysis of extracts of various cell lines, using C2 Antibody (CAB10186) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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