Cell Biology Antibodies 8
Anti-C1QTNF5 Antibody (CAB3021)
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- SKU:
- CAB3021
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-C1QTNF5 Antibody |
| Antibody SKU: | CAB3021 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-243 of human C1QTNF5 (NP_056460.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Mouse brain, Mouse kidney, Mouse uterus, Rat brain, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-243 of human C1QTNF5 (NP_056460.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SPPL DDNK IPSL CPGH PGLP GTPG HHGS QGLP GRDG RDGR DGAP GAPG EKGE GGRP GLPG PRGD PGPR GEAG PAGP TGPA GECS VPPR SAFS AKRS ESRV PPPS DAPL PFDR VLVN EQGH YDAV TGKF TCQV PGVY YFAV HATV YRAS LQFD LVKN GESI ASFF QFFG GWPK PASL SGGA MVRL EPED QVWV QVGV GDYI GIYA SIKT DSTF SGFL VYSD WHSS PVFA |
| Gene ID: | 114902 |
| Uniprot: | Q9BXJ0 |
| Cellular Location: | Secreted |
| Calculated MW: | 25kDa |
| Observed MW: | 36kDa |
| Synonyms: | C1QTNF5, CTRP5 |
| Background: | This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. |
| UniProt Protein Function: | Subunit structure: May interact with FAM132B |
| UniProt Protein Details: | By similarity. Homotrimer (via collagen-like domain). May form higher order oligomers by supercoiling of the trimers. Ref.10 Subcellular location: Secreted Probable. Involvement in Disease: Late-onset retinal degeneration (LORD) [MIM:605670]: Autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11 Miscellaneous: This protein is produced by a bicistronic gene which also produces the MFRP protein from a non-overlapping reading frame. Sequence similarities: Contains 1 C1q domain.Contains 1 collagen-like domain. |
| NCBI Summary: | This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q9BXJ0 |
| NCBI GenInfo Identifier: | 20177861 |
| NCBI Gene ID: | 114902 |
| NCBI Accession: | Q9BXJ0.1 |
| UniProt Secondary Accession: | Q9BXJ0,Q335M2, Q8N6P2, Q9UFX4, A6NDD3, B0YJ35, |
| UniProt Related Accession: | Q9BXJ0 |
| Molecular Weight: | 25,298 Da |
| NCBI Full Name: | Complement C1q tumor necrosis factor-related protein 5 |
| NCBI Synonym Full Names: | C1q and tumor necrosis factor related protein 5 |
| NCBI Official Symbol: | C1QTNF5 |
| NCBI Official Synonym Symbols: | CTRP5 |
| NCBI Protein Information: | complement C1q tumor necrosis factor-related protein 5; myonectin; C1q TNF-alpha-related protein 5 |
| UniProt Protein Name: | Complement C1q tumor necrosis factor-related protein 5 |
| UniProt Gene Name: | C1QTNF5 |
| UniProt Entry Name: | C1QT5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C1QTNF5 antibody (CAB3021) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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