ChIP Antibodies
Anti-C1QC Antibody (CAB9227)
- SKU:
- CAB9227
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C1QC Antibody |
| Antibody SKU: | CAB9227 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human C1QC (NP_001107573.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | Human serum |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human C1QC (NP_001107573.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YDGL PGPK GEPG IPAI PGIR GPKG QKGE PGLP GHPG KNGP MGPP GMPG VPGP MGIP GEPG EEGR YKQK FQSV FTVT RQTH QPPA PNSL IRFN AVLT NPQG D |
| Gene ID: | 714 |
| Uniprot: | P02747 |
| Cellular Location: | Secreted |
| Calculated MW: | 25kDa |
| Observed MW: | 26kDa |
| Synonyms: | C1QC, C1Q-C, C1QG |
| Background: | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. |
| UniProt Protein Function: | C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: collagen; extracellular region; extracellular space Biological Process: complement activation; complement activation, classical pathway; immune response; innate immune response; negative regulation of granulocyte differentiation; negative regulation of macrophage differentiation Disease: C1q Deficiency |
| NCBI Summary: | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02747 |
| NCBI GenInfo Identifier: | 20178281 |
| NCBI Gene ID: | 714 |
| NCBI Accession: | P02747.3 |
| UniProt Secondary Accession: | P02747,Q7Z502, Q96DL2, Q96H05, |
| UniProt Related Accession: | P02747 |
| Molecular Weight: | 25,774 Da |
| NCBI Full Name: | Complement C1q subcomponent subunit C |
| NCBI Synonym Full Names: | complement component 1, q subcomponent, C chain |
| NCBI Official Symbol: | C1QC |
| NCBI Official Synonym Symbols: | C1QG; C1Q-C |
| NCBI Protein Information: | complement C1q subcomponent subunit C |
| UniProt Protein Name: | Complement C1q subcomponent subunit C |
| Protein Family: | Complement C1q subcomponent |
| UniProt Gene Name: | C1QC |
| UniProt Entry Name: | C1QC_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon using C1QC antibody (CAB9227) at dilution of 1:100 (40x lens). |
View AllClose
Related Products
Anti-RANBP3 Antibody (CAB0092)
OverviewProduct Name:RANBP3 Rabbit mAbProduct Code:CAB0092Size:20uL, 50uL, 100uLSynonyms:RANBP3, ran-binding protein 3
Anti-QK1 Antibody (CAB0193)
OverviewProduct Name:QK1 Rabbit mAbProduct Code:CAB0193Size:20uL, 50uL, 100uLSynonyms:QKI, Hqk, QK, QK1, QK3, hqkI, protein quaking
Anti-DEK Antibody (CAB0315)
OverviewProduct Name:DEK Rabbit mAbProduct Code:CAB0315Size:20uL, 50uL, 100uLSynonyms:D6S231EApplications:WB,
Anti-EXOSC7 Antibody (CAB0501)
OverviewProduct Name:EXOSC7 Rabbit mAbProduct Code:CAB0501Size:20uL, 50uL, 100uLSynonyms:EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, exoso
Anti-Olig3 Antibody (CAB0600)
OverviewProduct Name:Olig3 Rabbit mAbProduct Code:CAB0600Size:20uL, 50uL, 100uLSynonyms:OLIG3, Bhlhb7, bHLHe20, oligodendrocyte transcri