ChIP Antibodies

Anti-C1QC Antibody (CAB9227)

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SKU:
CAB9227
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-C1QC Antibody
Antibody SKU:CAB9227
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human C1QC (NP_001107573.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:Human serum
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human C1QC (NP_001107573.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YDGL PGPK GEPG IPAI PGIR GPKG QKGE PGLP GHPG KNGP MGPP GMPG VPGP MGIP GEPG EEGR YKQK FQSV FTVT RQTH QPPA PNSL IRFN AVLT NPQG D
Gene ID:714
Uniprot:P02747
Cellular Location:Secreted
Calculated MW:25kDa
Observed MW:26kDa
Synonyms:C1QC, C1Q-C, C1QG
Background:This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene.
UniProt Protein Function:C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: collagen; extracellular region; extracellular space

Biological Process: complement activation; complement activation, classical pathway; immune response; innate immune response; negative regulation of granulocyte differentiation; negative regulation of macrophage differentiation

Disease: C1q Deficiency

NCBI Summary:This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P02747
NCBI GenInfo Identifier:20178281
NCBI Gene ID:714
NCBI Accession:P02747.3
UniProt Secondary Accession:P02747,Q7Z502, Q96DL2, Q96H05,
UniProt Related Accession:P02747
Molecular Weight:25,774 Da
NCBI Full Name:Complement C1q subcomponent subunit C
NCBI Synonym Full Names:complement component 1, q subcomponent, C chain
NCBI Official Symbol:C1QC  
NCBI Official Synonym Symbols:C1QG; C1Q-C  
NCBI Protein Information:complement C1q subcomponent subunit C
UniProt Protein Name:Complement C1q subcomponent subunit C
Protein Family:Complement C1q subcomponent
UniProt Gene Name:C1QC  
UniProt Entry Name:C1QC_HUMAN
Anti-C1QC Polyclonal Antibody (CAB9227)Immunohistochemistry of paraffin-embedded human colon using C1QC antibody (CAB9227) at dilution of 1:100 (40x lens).
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