Immunology Antibodies 2

Anti-C1QBP Antibody (CAB1883)

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SKU:
CAB1883
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-C1QBP Antibody
Antibody SKU:CAB1883
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 74-282 of human C1QBP (NP_001203.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:CEM, SW620, HeLa, Jurkat, Mouse liver, Mouse kidney, Mouse heart, Mouse intestine, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 74-282 of human C1QBP (NP_001203.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LHTD GDKA FVDF LSDE IKEE RKIQ KHKT LPKM SGGW ELEL NGTE AKLV RKVA GEKI TVTF NINN SIPP TFDG EEEP SQGQ KVEE QEPE LTST PNFV VEVI KNDD GKKA LVLD CHYP EDEV GQED EAES DIFS IREV SFQS TGES EWKD TNYT LNTD SLDW ALYD HLMD FLAD RGVD NTFA DELV ELST ALEH QEYI TFLE DLKS FVKS Q
Gene ID:708
Uniprot:Q07021
Cellular Location:Cell membrane, Cytoplasm, Extracellular side, Mitochondrion matrix, Nucleus, Peripheral membrane protein, Secreted, nucleolus
Calculated MW:31kDa
Observed MW:36kDa
Synonyms:C1QBP, GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
Background:The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.
UniProt Protein Function:C1QBP: a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. Originally identified via its binding interactions with Splicing Factor (SF-2). Multiple, diverse binding partners of C1QBP were subsequently identified, including the globular heads of complement component C1q, hyaluronic acid, selected protein kinases, the tumor suppressor ARF, and multiple antigens of bacterial and viral origin. Overexpressed in a number of cancer cell types, and has been implicated in the Warburg effect, whereby cancer cells shift their metabolism from oxidative phosphorylation to glycolysis. Inhibits the Mitochondrial Permeability Transition (MPT) pore, possibly serving a protective function against damage from oxidative stress. Binding to C1q inhibits C1. In complex with cytokeratin-1/KRT1 is a high affinty receptor for kininogen-1/HMWK. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. The cell surface form may require docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. Belongs to the MAM33 family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Receptor, misc.; Nucleolus; Mitochondrial

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cell surface; cytoplasm; cytosol; membrane; mitochondrion; nucleus; plasma membrane

Molecular Function:adrenergic receptor binding; complement component C1q binding; hyaluronic acid binding; kininogen binding; mRNA binding; protein binding; transcription corepressor activity; transcription factor binding

Biological Process: blood coagulation, intrinsic pathway; immune response; mature ribosome assembly; negative regulation of defense response to virus; negative regulation of interferon-gamma production; negative regulation of interleukin-12 production; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide 3-kinase cascade; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of protein kinase B signaling cascade; regulation of complement activation

NCBI Summary:The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]
UniProt Code:Q07021
NCBI GenInfo Identifier:730772
NCBI Gene ID:708
NCBI Accession:Q07021.1
UniProt Secondary Accession:Q07021,Q2HXR8, Q9NNY8,
UniProt Related Accession:Q07021
Molecular Weight:31,362 Da
NCBI Full Name:Complement component 1 Q subcomponent-binding protein, mitochondrial
NCBI Synonym Full Names:complement C1q binding protein
NCBI Official Symbol:C1QBP  
NCBI Official Synonym Symbols:p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R  
NCBI Protein Information:complement component 1 Q subcomponent-binding protein, mitochondrial
UniProt Protein Name:Complement component 1 Q subcomponent-binding protein, mitochondrial
UniProt Synonym Protein Names:ASF/SF2-associated protein p32; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; gC1q-R protein; p33
Protein Family:Complement component 1 Q subcomponent-binding protein
UniProt Gene Name:C1QBP  
UniProt Entry Name:C1QBP_HUMAN
Anti-C1QBP Antibody (CAB1883)Western blot analysis of extracts of various cell lines, using C1QBP antibody (CAB1883) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-C1QBP Antibody (CAB1883)Immunofluorescence analysis of HeLa cells using C1QBP antibody (CAB1883). Blue: DAPI for nuclear staining.
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