Immunology Antibodies 2

Anti-C1QB Antibody (CAB5339)

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SKU:
CAB5339
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-C1QB Antibody
Antibody SKU:CAB5339
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 104-253 of human C1QB (NP_000482.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 104-253 of human C1QB (NP_000482.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PGAP GPKG ESGD YKAT QKIA FSAT RTIN VPLR RDQT IRFD HVIT NMNN NYEP RSGK FTCK VPGL YYFT YHAS SRGN LCVN LMRG RERA QKVV TFCD YAYN TFQV TTGG MVLK LEQG ENVF LQAT DKNS LLGM EGAN SIFS GFLL FPDM EA
Gene ID:713
Uniprot:P02746
Cellular Location:Secreted
Calculated MW:26kDa
Observed MW:27kDa
Synonyms:C1QB
Background:This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q
UniProt Protein Function:C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; complement component C1 complex; extracellular region

Molecular Function:protein binding; protein homodimerization activity

Biological Process: complement activation; complement activation, classical pathway; innate immune response; inner ear development

Disease: C1q Deficiency

NCBI Summary:This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
UniProt Code:P02746
NCBI GenInfo Identifier:298286922
NCBI Gene ID:713
NCBI Accession:P02746.3
UniProt Secondary Accession:P02746,Q5T959, Q96H17,
UniProt Related Accession:P02746
Molecular Weight:26,722 Da
NCBI Full Name:Complement C1q subcomponent subunit B
NCBI Synonym Full Names:complement component 1, q subcomponent, B chain
NCBI Official Symbol:C1QB  
NCBI Protein Information:complement C1q subcomponent subunit B
UniProt Protein Name:Complement C1q subcomponent subunit B
Protein Family:Complement C1q subcomponent
UniProt Gene Name:C1QB  
UniProt Entry Name:C1QB_HUMAN
Anti-C1QB Antibody (CAB5339)Western blot analysis of extracts of mouse liver, using C1QB antibody (CAB5339) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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