Cell Death Antibodies 2
Anti-C1D Antibody (CAB6448)
- SKU:
- CAB6448
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-C1D Antibody |
| Antibody SKU: | CAB6448 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human C1D (NP_001177194.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human C1D (NP_001177194.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGE EINE DYPV EIHE YLSA FENS IGAV DEML KTMM SVSR NELL QKLD PLEQ AKVD LVSA YTLN SMFW VYLA TQGV NPKE HPVK QELE RIRV YMNR VKEI TDKK KAGK LDRG AASR FVKN ALWE PKSK NASK VANK GKSK S |
| Gene ID: | 10438 |
| Uniprot: | Q13901 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 16kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | C1D, LRP1, Rrp47, SUN-CoR, SUNCOR, hC1D |
| Background: | The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10. |
| UniProt Protein Function: | C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex) Molecular Function:ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q13901 |
| NCBI GenInfo Identifier: | 74754472 |
| NCBI Gene ID: | 10438 |
| NCBI Accession: | Q13901.1 |
| UniProt Secondary Accession: | Q13901,Q05D64, A8K336, D6W5F8, |
| UniProt Related Accession: | Q13901 |
| Molecular Weight: | 141 |
| NCBI Full Name: | Nuclear nucleic acid-binding protein C1D |
| NCBI Synonym Full Names: | C1D nuclear receptor corepressor |
| NCBI Official Symbol: | C1D |
| NCBI Official Synonym Symbols: | LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR |
| NCBI Protein Information: | nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor |
| UniProt Protein Name: | Nuclear nucleic acid-binding protein C1D |
| Protein Family: | Nuclear nucleic acid-binding protein |
| UniProt Gene Name: | C1D |
| UniProt Entry Name: | C1D_HUMAN |
 | Immunofluorescence analysis of U2OS cells using C1D antibody (CAB6448). Blue: DAPI for nuclear staining. |
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