Epigenetics & Nuclear Signaling Antibodies 4
Anti-C19orf40 Antibody (CAB8520)
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- SKU:
- CAB8520
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-C19orf40 Antibody |
| Antibody SKU: | CAB8520 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human C19orf40 (NP_689479.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human C19orf40 (NP_689479.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEKN PPDD TGPV HVPL GHIV ANEK WRGS QLAQ EMQG KIKL IFED GLTP DFYL SNRC CILY VTEA DLVA GNGY RKRL VRVR NSNN LKGI VVVE KTRM SEQY FPAL QKFT VLDL GMVL LPVA SQME ASCL VIQL VQEQ TKEP SKNP LLGK KRAL LLSE PSLL RTVQ QIPG VGKV KAPL LLQK FPSI QQLS NASI GELE QVVG QAVA QQIH AFFT QPR |
| Gene ID: | 91442 |
| Uniprot: | Q9BTP7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 23kDa |
| Observed MW: | 30kDa |
| Synonyms: | FAAP24, C19orf40 |
| Background: |
| UniProt Protein Function: | FAAP24: Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 19q13.11 Cellular Component: intracellular membrane-bound organelle; nucleoplasm Molecular Function:chromatin binding; protein binding |
| NCBI Summary: | FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BTP7 |
| NCBI GenInfo Identifier: | 74733136 |
| NCBI Gene ID: | 91442 |
| NCBI Accession: | Q9BTP7.2 |
| UniProt Secondary Accession: | Q9BTP7,Q8WUJ7, Q96FX6, B3KY46, |
| UniProt Related Accession: | Q9BTP7 |
| Molecular Weight: | 23,897 Da |
| NCBI Full Name: | Fanconi anemia core complex-associated protein 24 |
| NCBI Synonym Full Names: | Fanconi anemia core complex associated protein 24 |
| NCBI Official Symbol: | FAAP24 |
| NCBI Official Synonym Symbols: | C19orf40 |
| NCBI Protein Information: | Fanconi anemia core complex-associated protein 24 |
| UniProt Protein Name: | Fanconi anemia core complex-associated protein 24 |
| UniProt Synonym Protein Names: | Fanconi anemia-associated protein of 24 kDa |
| Protein Family: | Fanconi anemia core complex-associated protein |
| UniProt Gene Name: | FAAP24 |
| UniProt Entry Name: | FAP24_HUMAN |
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