Name: Anti-BVES Antibody (CAB0213)
Brand: Cell Biology Antibodies 1
SKU: CAB0213
Availability: OutOfStock

Antibody Name:	Anti-BVES Antibody
Antibody SKU:	CAB0213
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 241-360 of human BVES (NP_001186492.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	NCI-H460

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 241-360 of human BVES (NP_001186492.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	SEPF LYEI FRYL IGKD ITNK LYSL NDPT LNDK KAKK LEHQ LSLC TQIS MLEM RNSI ASSS DSDD GLHQ FLRG TSSM SSLH VSSP HQRA SAKM KPIE EGAE DDDD VFEP ASPN TLKV HQLP
Gene ID:	11149
Uniprot:	Q8NE79
Cellular Location:	Cell junction, Lateral cell membrane, Membrane, Multi-pass membrane protein, tight junction
Calculated MW:	41kDa
Observed MW:	70kDa

Synonyms:

BVES, HBVES, LGMD2X, POP1, POPDC1

Background:

This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene.

UniProt Protein Function:	BVES: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Belongs to the popeye family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6q21 Cellular Component: tight junction; plasma membrane; integral to membrane; lateral plasma membrane Molecular Function:cAMP binding; structural molecule activity Biological Process: vesicle-mediated transport; regulation of cell shape; regulation of membrane potential; muscle development; positive regulation of locomotion; regulation of heart rate; hemopoietic progenitor cell differentiation; positive regulation of receptor recycling
NCBI Summary:	This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:	Q8NE79
NCBI GenInfo Identifier:	38257661
NCBI Gene ID:	11149
NCBI Accession:	Q8NE79.1
UniProt Related Accession:	Q8NE79
Molecular Weight:
NCBI Full Name:	Blood vessel epicardial substance
NCBI Synonym Full Names:	blood vessel epicardial substance
NCBI Official Symbol:	BVES
NCBI Official Synonym Symbols:	POP1; HBVES; CARICK; LGMD2X; POPDC1; LGMDR25
NCBI Protein Information:	blood vessel epicardial substance
UniProt Protein Name:	Blood vessel epicardial substance
UniProt Synonym Protein Names:	Popeye domain-containing protein 1; Popeye protein 1
Protein Family:	Blood vessel epicardial substance
UniProt Gene Name:	BVES
UniProt Entry Name:	POPD1_HUMAN

Western blot analysis of extracts of NCI-H460 cells, using BVES antibody (CAB0213) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s.

Antibodies

BVES Antibody (PACO08066)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)