Immunology Antibodies 1

Anti-BTN3A1 Antibody (CAB10288)

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SKU:
CAB10288
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-BTN3A1 Antibody
Antibody SKU:CAB10288
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-250 of human BTN3A1 (NP_008979.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, HepG2, HL-60, U-937
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-250 of human BTN3A1 (NP_008979.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILAM VGED ADLP CHLF PTMS AETM ELKW VSSS LRQV VNVY ADGK EVED RQSA PYRG RTSI LRDG ITAG KAAL RIHN VTAS DSGK YLCY FQDG DFYE KALV ELKV AALG SDLH VDVK GYKD GGIH LECR STGW YPQP QIQW SNNK GENI PTVE APVV ADGV GLYA VAAS VIMR GSSG EGVS CTIR SSLL GLEK TASI SIAD PFFR SAQR WIA
Gene ID:11119
Uniprot:O00481
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:39kDa/41kDa/52kDa/57kDa
Observed MW:56kDa
Synonyms:BTN3A1, BT3.1, BTF5, BTN3.1, CD277
Background:
UniProt Protein Function:Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
NCBI Summary:The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
UniProt Code:O00481
NCBI GenInfo Identifier:117949374
NCBI Gene ID:11119
NCBI Accession:O00481.3
UniProt Secondary Accession:O00481,Q0P515, Q147X5, Q53F15, Q99420, Q9HCY1, A2A278 A8K2C8, B4DIQ1, B4DRM2, E9PGB4, E9PHG8,
UniProt Related Accession:O00481
Molecular Weight:52,019 Da
NCBI Full Name:Butyrophilin subfamily 3 member A1
NCBI Synonym Full Names:butyrophilin subfamily 3 member A1
NCBI Official Symbol:BTN3A1  
NCBI Official Synonym Symbols:BTF5; BT3.1; CD277; BTN3.1  
NCBI Protein Information:butyrophilin subfamily 3 member A1
UniProt Protein Name:Butyrophilin subfamily 3 member A1
UniProt Synonym Protein Names:CD_antigen: CD277
UniProt Gene Name:BTN3A1  
Anti-BTN3A1 Antibody (CAB10288)Western blot analysis of extracts of various cell lines, using BTN3A1 antibody (CAB10288) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-BTN3A1 Antibody (CAB10288)Immunofluorescence analysis of rat lung using BTN3A1 Polyclonal Antibody (CAB10288) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-BTN3A1 Antibody (CAB10288)Immunofluorescence analysis of mouse lung using BTN3A1 Polyclonal Antibody (CAB10288) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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