Cell Biology Antibodies 8

Anti-BTC Antibody (CAB2588)

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SKU:
CAB2588
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BTC Antibody
Antibody SKU:CAB2588
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-178 of human BTC (NP_001720.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:OVCAR3, PC-3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-178 of human BTC (NP_001720.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DGNS TRSP ETNG LLCG DPEE NCAA TTTQ SKRK GHFS RCPK QYKH YCIK GRCR FVVA EQTP SCVC DEGY IGAR CERV DLFY LRGD RGQI LVIC LIAV MVVF IILV IGVC TCCH PLRK RRKR KKKE EEME TLGK DITP INED IEET NIA
Gene ID:685
Uniprot:P35070
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space
Calculated MW:19kDa
Observed MW:20kDa
Synonyms:BTC
Background:This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.
UniProt Protein Function:BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
UniProt Protein Details:

Protein type:Ligand, receptor tyrosine kinase; Cell cycle regulation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; plasma membrane; integral to membrane; extracellular region

Molecular Function:protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of cell proliferation; innate immune response; positive regulation of cell differentiation; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008]
UniProt Code:P35070
NCBI GenInfo Identifier:461653
NCBI Gene ID:685
NCBI Accession:P35070.1
UniProt Secondary Accession:P35070,Q96F48,
UniProt Related Accession:P35070
Molecular Weight:19,746 Da
NCBI Full Name:Probetacellulin
NCBI Synonym Full Names:betacellulin
NCBI Official Symbol:BTC  
NCBI Protein Information:probetacellulin
UniProt Protein Name:Probetacellulin
Protein Family:Probetacellulin
UniProt Gene Name:BTC  
UniProt Entry Name:BTC_HUMAN
Anti-BTC Antibody (CAB2588)Western blot analysis of extracts of various cell lines, using BTC antibody (CAB2588) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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