Epigenetics & Nuclear Signaling Antibodies 1
Anti-BRWD1 Antibody (CAB12656)
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- SKU:
- CAB12656
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-BRWD1 Antibody |
| Antibody SKU: | CAB12656 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human BRWD1 (NP_001007247.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Jurkat, SGC-7901, NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human BRWD1 (NP_001007247.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEP SSAR RPVP LIES ELYF LIAR YLSA GPCR RAAQ VLVQ ELEQ YQLL PKRL DWEG NEHN RSYE ELVL SNKH VAPD HLLQ ICQR IGPM LDKE IPPS ISRV TSLL GAGR QSLL RTAK GTLI |
| Gene ID: | 54014 |
| Uniprot: | Q9NSI6 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 13kDa/248kDa/257kDa/262kDa |
| Observed MW: | 263kDa |
| Synonyms: | BRWD1, C21orf107, DCAF19, N143, WDR9 |
| Background: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex. |
| UniProt Protein Function: | May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011] |
| UniProt Code: | Q9NSI6 |
| NCBI GenInfo Identifier: | 313104296 |
| NCBI Gene ID: | 54014 |
| NCBI Accession: | Q9NSI6.4 |
| UniProt Secondary Accession: | Q9NSI6,O43721, Q5R2V0, Q5R2V1, Q6P2D1, Q8TCV3, Q96QG9 Q96QH0, Q9NUK1, C9JK25, |
| UniProt Related Accession: | Q9NSI6 |
| Molecular Weight: | 263kDa |
| NCBI Full Name: | Bromodomain and WD repeat-containing protein 1 |
| NCBI Synonym Full Names: | bromodomain and WD repeat domain containing 1 |
| NCBI Official Symbol: | BRWD1 |
| NCBI Official Synonym Symbols: | N143; WDR9; DCAF19; C21orf107 |
| NCBI Protein Information: | bromodomain and WD repeat-containing protein 1 |
| UniProt Protein Name: | Bromodomain and WD repeat-containing protein 1 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 9 |
| Protein Family: | Bromodomain and WD repeat-containing protein |
| UniProt Gene Name: | BRWD1 |
 | Western blot analysis of extracts of various cell lines, using BRWD1 antibody (CAB12656) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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