Immunology Antibodies 2

Anti-BRD2 Antibody (CAB16241)

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SKU:
CAB16241
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-BRD2 Antibody
Antibody SKU:CAB16241
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRD2 (NP_001186385.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse brian
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRD2 (NP_001186385.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASV PALQ LTPA NPPP PEVS NPKK PGRV TNQL QYLH KVVM KALW KHQF AWPF RQPV DAVK LGLP DYHK IIKQ PMDM GTIK RRLE NNYY WAAS ECMQ DFNT
Gene ID:6046
Uniprot:P25440
Cellular Location:Nucleus
Calculated MW:74kDa/83kDa/88kDa/92kDa
Observed MW:110kDa
Synonyms:BRD2, BRD2-IT1, D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3
Background:This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
UniProt Protein Function:May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
NCBI Summary:This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:P25440
NCBI GenInfo Identifier:12230989
NCBI Gene ID:6046
NCBI Accession:P25440.2
UniProt Secondary Accession:P25440,O00699, O00700, Q15310, Q5STC9, Q63HQ9, Q658Y7 Q6P3U2, Q969U4, A2AAU0, B0S7P0, B1AZT1,
UniProt Related Accession:P25440
Molecular Weight:74,881 Da
NCBI Full Name:Bromodomain-containing protein 2
NCBI Synonym Full Names:bromodomain containing 2
NCBI Official Symbol:BRD2  
NCBI Official Synonym Symbols:FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1  
NCBI Protein Information:bromodomain-containing protein 2
UniProt Protein Name:Bromodomain-containing protein 2
UniProt Synonym Protein Names:O27.1.1; Really interesting new gene 3 protein
Protein Family:Bromodomain-containing protein
UniProt Gene Name:BRD2  
UniProt Entry Name:BRD2_HUMAN
Anti-BRD2 Antibody (CAB16241)Western blot analysis of extracts of mouse brian, using BRD2 antibody (CAB16241) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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