Immunology Antibodies 3

Anti-BRD1 Antibody (CAB9869)

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SKU:
CAB9869
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-BRD1 Antibody
Antibody SKU:CAB9869
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human BRD1 (NP_055392.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human BRD1 (NP_055392.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRRK GRCH RGSA ARHP SSPC SVKH SPTR ETLT YAQA QRMV EIEI EGRL HRIS IFDP LEII LEDD LTAQ EMSE CNSN KENS ERPP VCLR TKRH KNNR VKKK NEAL PSAH GTPA SASA LPEP KVRI VEYS PPSA PRRP PVYY KFIE KSAE ELDN EVEY DMDE EDYA WLEI VNEK RKGD CVPA VSQS MFEF LMDR FEKE SHCE NQKQ GEQQ SLID EDAV CCIC MDGE CQNS NVIL FCDM CNLA VHQE CYGV PY
Gene ID:23774
Uniprot:O95696
Cellular Location:Nucleus
Calculated MW:119kDa/133kDa
Observed MW:150kDa
Synonyms:BRD1, BRL, BRPF1, BRPF2
Background:This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:BRD1: a nuclear protein containing a bromo-domain, a PHD domain, and a PWWP domain. Encoded by a susceptibility gene for schizophrenia and bipolar affective disorder. May play a role in neurodevelopment.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; nucleus

Molecular Function:histone binding

NCBI Summary:This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Code:O95696
NCBI GenInfo Identifier:12229697
NCBI Gene ID:23774
NCBI Accession:O95696.1
UniProt Secondary Accession:O95696,A6ZJA4,
UniProt Related Accession:O95696
Molecular Weight:133,243 Da
NCBI Full Name:Bromodomain-containing protein 1
NCBI Synonym Full Names:bromodomain containing 1
NCBI Official Symbol:BRD1  
NCBI Official Synonym Symbols:BRL; BRPF1; BRPF2  
NCBI Protein Information:bromodomain-containing protein 1
UniProt Protein Name:Bromodomain-containing protein 1
UniProt Synonym Protein Names:BR140-like protein; Bromodomain and PHD finger-containing protein 2
UniProt Gene Name:BRD1  
UniProt Entry Name:BRD1_HUMAN
Anti-BRD1 Polyclonal Antibody (CAB9869)Western blot analysis of extracts of various cell lines, using BRD1 antibody (CAB9869) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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