Cell Biology Antibodies 9
Anti-BPI Antibody (CAB5338)
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- SKU:
- CAB5338
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BPI Antibody |
| Antibody SKU: | CAB5338 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, HepG2, SK-Hep1, Mouse liver, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AETL DVQM KGEF YSEN HHNP PPFA PPVM EFPA AHDR MVYL GLSD YFFN TAGL VYQE AGVL KMTL RDDM IPKE SKFR LTTK FFGT FLPE VAKK FPNM KIQI HVSA STPP HLSV QPTG LTFY PAVD VQAF AVLP NSSL ASLF LIGM HTTG SMEV SAES NRLV GELK LDRL LLEL KHSN IGPF PVEL LQDI MNYI VPIL VLPR VNEK LQKG FPLP TPAR VQLY NVVL QPHQ NFLL FGAD VVYK |
| Gene ID: | 671 |
| Uniprot: | P17213 |
| Cellular Location: | Cytoplasmic granule membrane, Secreted |
| Calculated MW: | 53kDa |
| Observed MW: | 55kDa |
| Synonyms: | BPI, BPIFD1, rBPI |
| Background: | This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. |
| UniProt Protein Function: | BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. |
| UniProt Protein Details: | Protein type:Cell surface; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: integral to plasma membrane Molecular Function:lipopolysaccharide binding Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production |
| NCBI Summary: | This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P17213 |
| NCBI GenInfo Identifier: | 215274242 |
| NCBI Gene ID: | 671 |
| NCBI Accession: | P17213.4 |
| UniProt Secondary Accession: | P17213,Q1ZZU8, Q5JRW0, Q8IW58, Q9BYZ9, Q9H1L2, Q9H1M8 Q9H203, Q9UCT4, Q9UD65, B2RCY2, |
| UniProt Related Accession: | P17213 |
| Molecular Weight: | |
| NCBI Full Name: | Bactericidal permeability-increasing protein |
| NCBI Synonym Full Names: | bactericidal/permeability-increasing protein |
| NCBI Official Symbol: | BPI |
| NCBI Official Synonym Symbols: | rBPI; BPIFD1 |
| NCBI Protein Information: | bactericidal permeability-increasing protein |
| UniProt Protein Name: | Bactericidal permeability-increasing protein |
| UniProt Synonym Protein Names: | CAP 57 |
| Protein Family: | BPI fold-containing family |
| UniProt Gene Name: | BPI |
| UniProt Entry Name: | BPI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BPI antibody (CAB5338) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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