Cell Death Antibodies 2
Anti-BNIP3L Antibody (CAB6283)
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- SKU:
- CAB6283
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-BNIP3L Antibody |
| Antibody SKU: | CAB6283 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human BNIP3L (NP_004322.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, A-549, MCF7, Raji, Mouse spleen, Mouse thymus, Mouse brain, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human BNIP3L (NP_004322.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSH LVEP PPPL HNNN NNCE ENEQ SLPP PAGL NSSW VELP MNSS NGND NGNG KNGG LEHV PSSS SIHN GDME KILL DAQH ESGQ SSSR GSSH CDSP SPQE DGQI MFDV EMHT SRDH SSQS EEEV VEGE KEVE ALKK SADW VSDW SSRP ENIP PKEF HFRH PKRS VSLS MRKS GAMK KGGI FSAE FLK |
| Gene ID: | 665 |
| Uniprot: | O60238 |
| Cellular Location: | Endoplasmic reticulum, Membrane, Mitochondrion outer membrane, Nucleus envelope, Single-pass membrane protein |
| Calculated MW: | 19kDa/23kDa |
| Observed MW: | 30kDa/45kDa |
| Synonyms: | BNIP3L, BNIP3a, NIX |
| Background: | This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. |
| UniProt Protein Function: | BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis; Membrane protein, integral; Nuclear envelope; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 8p21 Cellular Component: endoplasmic reticulum; intrinsic to membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope Molecular Function:identical protein binding; lamin binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: defense response to virus; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; regulation of apoptosis |
| NCBI Summary: | This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015] |
| UniProt Code: | O60238 |
| NCBI GenInfo Identifier: | 6093509 |
| NCBI Gene ID: | 665 |
| NCBI Accession: | O60238.1 |
| UniProt Secondary Accession: | O60238,Q5JW63, Q8NF87, B0AZS9, |
| UniProt Related Accession: | O60238 |
| Molecular Weight: | 19,559 Da |
| NCBI Full Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
| NCBI Synonym Full Names: | BCL2 interacting protein 3 like |
| NCBI Official Symbol: | BNIP3L |
| NCBI Official Synonym Symbols: | NIX; BNIP3a |
| NCBI Protein Information: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
| UniProt Protein Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
| UniProt Synonym Protein Names: | Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3L |
| Protein Family: | BCL2/adenovirus E1B 19 kDa protein-interacting protein |
| UniProt Gene Name: | BNIP3L |
| UniProt Entry Name: | BNI3L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BNIP3L antibody (CAB6283) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human stomach using BNIP3L antibody (CAB6283) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using BNIP3L antibody (CAB6283) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using BNIP3L antibody (CAB6283) at dilution of 1:100 (40x lens). |
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