Cell Death Antibodies 2
Anti-BNIP2 Antibody (CAB6282)
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- SKU:
- CAB6282
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-BNIP2 Antibody |
| Antibody SKU: | CAB6282 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-280 of human BNIP2 (NP_004321.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-937, SW480, NCI-H460, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-280 of human BNIP2 (NP_004321.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VELK EEWQ DEDF PIPL PEDD SIEA DILA ITGP EDQP GSLE VNGN KVRK KLMA PDIS LTLD PSDG SVLS DDLD ESGE IDLD GLDT PSEN SNEF EWED DLPK PKTT EVIR KGSI TEYT AAEE KEDG RRWR MFRI GEQD HRVD MKAI EPYK KVIS HGGY |
| Gene ID: | 663 |
| Uniprot: | Q12982 |
| Cellular Location: | Cytoplasm, perinuclear region |
| Calculated MW: | 36kDa/43kDa |
| Observed MW: | 45-55kDa |
| Synonyms: | BNIP2, BNIP-2, NIP2 |
| Background: | This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | BNIP2: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Apoptosis Chromosomal Location of Human Ortholog: 15q22.2 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nuclear envelope Molecular Function:calcium ion binding; GTPase activator activity; identical protein binding; protein binding Biological Process: apoptosis; negative regulation of apoptosis; positive regulation of muscle cell differentiation |
| NCBI Summary: | This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q12982 |
| NCBI GenInfo Identifier: | 6093506 |
| NCBI Gene ID: | 663 |
| NCBI Accession: | Q12982.1 |
| UniProt Secondary Accession: | Q12982,B4DS94, |
| UniProt Related Accession: | Q12982 |
| Molecular Weight: | 43,135 Da |
| NCBI Full Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 |
| NCBI Synonym Full Names: | BCL2 interacting protein 2 |
| NCBI Official Symbol: | BNIP2 |
| NCBI Official Synonym Symbols: | NIP2; BNIP-2 |
| NCBI Protein Information: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 |
| UniProt Protein Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 |
| Protein Family: | BCL2/adenovirus E1B 19 kDa protein-interacting protein |
| UniProt Gene Name: | BNIP2 |
| UniProt Entry Name: | BNIP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BNIP2 antibody (CAB6282) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using BNIP2 antibody (CAB6282). Blue: DAPI for nuclear staining. |
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