Cell Biology Antibodies 1
Anti-BMP7 Antibody (CAB0697)
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- SKU:
- CAB0697
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BMP7 Antibody |
| Antibody SKU: | CAB0697 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 132-431 of human BMP7 (NP_001710.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF-7, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 132-431 of human BMP7 (NP_001710.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVMS FVNL VEHD KEFF HPRY HHRE FRFD LSKI PEGE AVTA AEFR IYKD YIRE RFDN ETFR ISVY QVLQ EHLG RESD LFLL DSRT LWAS EEGW LVFD ITAT SNHW VVNP RHNL GLQL SVET LDGQ SINP KLAG LIGR HGPQ NKQP FMVA FFKA TEVH FRSI RSTG SKQR SQNR SKTP KNQE ALRM ANVA ENSS SDQR QACK KHEL YVSF RDLG WQDW IIAP EGYA AYYC EGEC AFPL NSYM NATN HAIV QTLV HFIN PETV PKPC CAPT QLNA ISVL YFDD SSNV ILKK YRNM VVRA CGCH |
| Gene ID: | 655 |
| Uniprot: | P18075 |
| Cellular Location: | Secreted |
| Calculated MW: | 49kDa |
| Observed MW: | 49kDa |
| Synonyms: | BMP7, OP-1 |
| Background: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. |
| UniProt Code: | P18075 |
| NCBI GenInfo Identifier: | 115078 |
| NCBI Gene ID: | 655 |
| NCBI Accession: | P18075.1 |
| UniProt Secondary Accession: | P18075,Q9H512, Q9NTQ7, |
| UniProt Related Accession: | P18075 |
| Molecular Weight: | 431 |
| NCBI Full Name: | Bone morphogenetic protein 7 |
| NCBI Synonym Full Names: | bone morphogenetic protein 7 |
| NCBI Official Symbol: | BMP7 |
| NCBI Official Synonym Symbols: | OP-1 |
| NCBI Protein Information: | bone morphogenetic protein 7; osteogenic protein 1 |
| UniProt Protein Name: | Bone morphogenetic protein 7 |
| UniProt Synonym Protein Names: | Osteogenic protein 1; OP-1; INN: Eptotermin alfa |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP7 |
| UniProt Entry Name: | BMP7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BMP7 antibody (CAB0697) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using BMP7 Rabbit pAb (CAB0697) at dilution of 1:100 (40x lens). |
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