Cell Biology Antibodies 12

Anti-BMP5 Antibody (CAB8401)

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SKU:
CAB8401
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BMP5 Antibody
Antibody SKU:CAB8401
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 317-454 of human BMP5 (NP_066551.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:H460, LO2, SW620, 293T, mouse liver, mouse small intestine, mouse skeletal muscle, rat lung, rat liver, NCI-H460, Mouse lung, Mouse liver, Mouse small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 317-454 of human BMP5 (NP_066551.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AANK RKNQ NRNK SSSH QDSS RMSS VGDY NTSE QKQA CKKH ELYV SFRD LGWQ DWII APEG YAAF YCDG ECSF PLNA HMNA TNHA IVQT LVHL MFPD HVPK PCCA PTKL NAIS VLYF DDSS NVIL KKYR NMVV RSCG CH
Gene ID:653
Uniprot:P22003
Cellular Location:Secreted
Calculated MW:47kDa/51kDa
Observed MW:52kDa
Synonyms:BMP5
Background:This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
UniProt Protein Function:BMP5: Induces cartilage and bone formation. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: extracellular space

Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: ossification; negative regulation of insulin-like growth factor receptor signaling pathway; pattern specification process; regulation of apoptosis; BMP signaling pathway; negative regulation of cell proliferation; cartilage development; regulation of MAPKKK cascade; negative regulation of aldosterone biosynthetic process; male genitalia development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; positive regulation of epithelial cell proliferation; growth

NCBI Summary:This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]
UniProt Code:P22003
NCBI GenInfo Identifier:115075
NCBI Gene ID:653
NCBI Accession:P22003.1
UniProt Secondary Accession:P22003,Q9H547, Q9NTM5, B4E0Y4,
UniProt Related Accession:P22003
Molecular Weight:47,670 Da
NCBI Full Name:Bone morphogenetic protein 5
NCBI Synonym Full Names:bone morphogenetic protein 5
NCBI Official Symbol:BMP5  
NCBI Protein Information:bone morphogenetic protein 5; BMP-5; bone morphogenenic protein-5
UniProt Protein Name:Bone morphogenetic protein 5
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP5  
UniProt Entry Name:BMP5_HUMAN
Anti-BMP5 Polyclonal Antibody (CAB8401)Western blot analysis of extracts of various cell lines, using BMP5 antibody (CAB8401) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-BMP5 Polyclonal Antibody (CAB8401)Immunohistochemistry of paraffin-embedded rat lung using BMP5 antibody (CAB8401) at dilution of 1:100 (40x lens).
Anti-BMP5 Polyclonal Antibody (CAB8401)Immunohistochemistry of paraffin-embedded human prostate using BMP5 antibody (CAB8401) at dilution of 1:100 (40x lens).
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