Cell Biology Antibodies 6

Anti-BMP2K Antibody (CAB15860)

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SKU:
CAB15860
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BMP2K Antibody
Antibody SKU:CAB15860
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human BMP2K (NP_060063.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human BMP2K (NP_060063.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SDNV WEVL ILME YCRA GQVV NQMN KKLQ TGFT EPEV LQIF CDTC EAVA RLHQ CKTP IIHR DLKV ENIL LNDG GNYV LCDF GSAT NKFL NPQK DGVN VVEE EIKK YTTL SYRA PEMI NLYG GKPI TTKA DIWA LGCL LYKL CFFT LPFG ESQV AICD GNFT IPDN SRYS RNIH CLIR FMLE PDPE HRPD IFQV SYFA FKFA KKDC PVSN INNS SIPS ALPE PMTA SEAA ARKS QIKA RITD TIGP TETS IAPR QRPK ANSA TTAT PSVL TIQS SATP VKVL APGE FGNH RPKG ALRP GNGP E
Gene ID:55589
Uniprot:Q9NSY1
Cellular Location:Nucleus
Calculated MW:73kDa/75kDa/129kDa
Observed MW:Refer to figures
Synonyms:BMP2K, BIKE, HRIHFB2017
Background:This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:BIKE: May be involved in osteoblast differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NAK family

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: nucleoplasm; nucleus

Molecular Function:phosphatase regulator activity; protein serine/threonine kinase activity

Biological Process: protein amino acid phosphorylation; regulation of bone mineralization

NCBI Summary:This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NSY1
NCBI GenInfo Identifier:34222653
NCBI Gene ID:55589
NCBI Accession:Q9NSY1.2
UniProt Secondary Accession:Q9NSY1,O94791, Q4W5H2, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8
UniProt Related Accession:Q9NSY1
Molecular Weight:75,812 Da
NCBI Full Name:BMP-2-inducible protein kinase
NCBI Synonym Full Names:BMP2 inducible kinase
NCBI Official Symbol:BMP2K  
NCBI Official Synonym Symbols:BIKE; HRIHFB2017  
NCBI Protein Information:BMP-2-inducible protein kinase
UniProt Protein Name:BMP-2-inducible protein kinase
Protein Family:BMP-2-inducible protein kinase
UniProt Gene Name:BMP2K  
UniProt Entry Name:BMP2K_HUMAN
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