Cell Biology Antibodies 11

Anti-BMP15 Antibody (CAB7321)

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SKU:
CAB7321
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BMP15 Antibody
Antibody SKU:CAB7321
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human BMP15 (NP_005439.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:OVCAR3, Mouse brain, Mouse kidney, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human BMP15 (NP_005439.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LTRF NLSC HVEP WVQK NPTN HFPS SEGD SSKP SLMS NAWK EMDI TQLV QQRF WNNK GHRI LRLR FMCQ QQKD SGGL ELWH GTSS LDIA FLLL YFND THKS IRKA KFLP RGME EFME RESL LRRT RQAD GISA EVTA SSSK HSGP ENNQ CSLH PFQI SFRQ LGWD HWII APPF YTPN YCKG TCLR VLRD GLNS PNHA IIQN LINQ LVDQ SVPR PSCV PYKY VPIS VLMI EANG SILY KEYE GMIA ESCT CR
Gene ID:9210
Uniprot:O95972
Cellular Location:Secreted
Calculated MW:45kDa
Observed MW:45-50kDa
Synonyms:BMP15, GDF9B, ODG2, POF4
Background:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
UniProt Protein Function:BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: extracellular space; cytoplasm

Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; granulosa cell development; ovarian follicle development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development

Disease: Ovarian Dysgenesis 2

NCBI Summary:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
UniProt Code:O95972
NCBI GenInfo Identifier:51338749
NCBI Gene ID:9210
NCBI Accession:O95972.2
UniProt Related Accession:O95972
Molecular Weight:
NCBI Full Name:Bone morphogenetic protein 15
NCBI Synonym Full Names:bone morphogenetic protein 15
NCBI Official Symbol:BMP15  
NCBI Official Synonym Symbols:ODG2; POF4; GDF9B  
NCBI Protein Information:bone morphogenetic protein 15
UniProt Protein Name:Bone morphogenetic protein 15
UniProt Synonym Protein Names:Growth/differentiation factor 9B
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP15  
UniProt Entry Name:BMP15_HUMAN
Anti-BMP15 Antibody (CAB7321)Western blot analysis of extracts of various cell lines, using BMP15 antibody (CAB7321) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
Anti-BMP15 Antibody (CAB7321)Immunohistochemistry of paraffin-embedded rat kidney using BMP15 antibody (CAB7321) at dilution of 1:100 (40x lens).
Anti-BMP15 Antibody (CAB7321)Immunohistochemistry of paraffin-embedded human kidney using BMP15 antibody (CAB7321) at dilution of 1:100 (40x lens).
Anti-BMP15 Antibody (CAB7321)Immunohistochemistry of paraffin-embedded human stomach using BMP15 antibody (CAB7321) at dilution of 1:100 (40x lens).
Anti-BMP15 Antibody (CAB7321)Immunohistochemistry of paraffin-embedded mouse kidney using BMP15 antibody (CAB7321) at dilution of 1:100 (40x lens).
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