Cell Biology Antibodies 5

Anti-BMP10 Antibody (CAB15010)

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SKU:
CAB15010
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BMP10 Antibody
Antibody SKU:CAB15010
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SPIM NLEQ SPLE EDMS LFGD VFSE QDGV DFNT LLQS MKDE FLKT LNLS DIPT QDSA KVDP PEYM LELY NKFA TDRT SMPS ANII RSFK NEDL FSQP VSFN GLRK YPLL FNVS IPHH EEVI MAEL RLYT LVQR DRMI YDGV DRKI TIFE VLES KGDN EGER NMLV LVSG EIYG TNSE WETF DVTD AIRR WQKS GSST HQLE VHIE SKHD EAED ASSG RLEI DTSA QNKH NPLL IVFS DDQS SDKE RKEE LNEM ISHE QLPE LDNL GLDS FSSG PGEE ALLQ MRSN IIYD STAR IRR
Gene ID:27302
Uniprot:O95393
Cellular Location:Secreted
Calculated MW:48kDa
Observed MW:48kDa
Synonyms:BMP10
Background:The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases.
UniProt Protein Function:Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
NCBI Summary:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]
UniProt Code:O95393
NCBI GenInfo Identifier:13123977
NCBI Gene ID:27302
NCBI Accession:O95393.1
UniProt Secondary Accession:O95393,Q53R17, Q6NTE0,
UniProt Related Accession:O95393
Molecular Weight:48,047 Da
NCBI Full Name:Bone morphogenetic protein 10
NCBI Synonym Full Names:bone morphogenetic protein 10
NCBI Official Symbol:BMP10  
NCBI Protein Information:bone morphogenetic protein 10
UniProt Protein Name:Bone morphogenetic protein 10
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP10  
Anti-BMP10 Antibody (CAB15010)Western blot analysis of extracts of rat heart, using BMP10 antibody (CAB15010) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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