Cell Death Antibodies 1
Anti-BMF Antibody (CAB12907)
- SKU:
- CAB12907
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-BMF Antibody |
| Antibody SKU: | CAB12907 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human BMF (NP_277038.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human BMF (NP_277038.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEPS QCVE ELED DVFQ PEDG EPVT QPGS LLSA DLFA QSLL DCPL SRLQ LFPL THCC GPGL RPTS QEDK ATQT LSPA SPSQ GVML PCGV TEEP QRLF YGNA GYRL PLPA SFPA VLPI GEQP PEGQ WQHQ AEVQ IARK LQCI ADQF HRLH VQQH QQNQ NRVW WQIL LFLH NLAL NGEE NRNG AGPR |
| Gene ID: | 90427 |
| Uniprot: | Q96LC9 |
| Cellular Location: | |
| Calculated MW: | 14kDa/17kDa/20kDa |
| Observed MW: |
| Synonyms: | BMF |
| Background: | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Cytoskeletal Chromosomal Location of Human Ortholog: 15q14 Cellular Component: mitochondrial outer membrane; plasma membrane; acrosome; cytosol; myosin complex Molecular Function:protein binding Biological Process: positive regulation of protein homooligomerization; apoptosis; anoikis |
| NCBI Summary: | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96LC9 |
| NCBI GenInfo Identifier: | 56748563 |
| NCBI Gene ID: | 90427 |
| NCBI Accession: | Q96LC9.1 |
| UniProt Secondary Accession: | Q96LC9,Q2M396, Q6NT30, Q6NT56, Q6P9F6, Q7Z7D4, Q7Z7D5 Q9H7K7, |
| UniProt Related Accession: | Q96LC9 |
| Molecular Weight: | 184 |
| NCBI Full Name: | Bcl-2-modifying factor |
| NCBI Synonym Full Names: | Bcl2 modifying factor |
| NCBI Official Symbol: | BMF |
| NCBI Protein Information: | bcl-2-modifying factor |
| UniProt Protein Name: | Bcl-2-modifying factor |
| Protein Family: | Bcl-2-modifying factor |
| UniProt Gene Name: | BMF |
| UniProt Entry Name: | BMF_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver cancer using BMF antibody (CAB12907) at dilution of 1:200 (40x lens). |
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