Cell Biology Antibodies 4

Anti-BLOC1S1 Antibody (CAB13986)

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SKU:
CAB13986
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-BLOC1S1 Antibody
Antibody SKU:CAB13986
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-153 of human BLOC1S1 (NP_001478.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-153 of human BLOC1S1 (NP_001478.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLSR LLKE HQAK QNER KELQ EKRR REAI TAAT CLTE ALVD HLNV GVAQ AYMN QRKL DHEV KTLQ VQAA QFAK QTGQ WIGM VENF NQAL KEIG DVEN WARS IELD MRTI ATAL EYVY KGQL QSAP S
Gene ID:2647
Uniprot:P78537
Cellular Location:Cytoplasm, Mitochondrion intermembrane space, Mitochondrion matrix, cytosol
Calculated MW:14kDa/17kDa
Observed MW:Refer to figures
Synonyms:BLOC1S1, BLOS1, BORCS1, GCN5L1, MICoA, RT14
Background:
UniProt Protein Function:BLOC1S1: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system. Belongs to the BLOC1S1 family. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Vesicle

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: extracellular space; lysosomal membrane; mitochondrial matrix; mitochondrial intermembrane space; cytosol

Molecular Function:protein binding

Biological Process: platelet dense granule organization and biogenesis; melanosome organization and biogenesis; anterograde synaptic vesicle transport; aerobic respiration; post-Golgi vesicle-mediated transport; anterograde axon cargo transport; peptidyl-lysine acetylation; neurite development

NCBI Summary:BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM, Mar 2008]
UniProt Code:P78537
NCBI GenInfo Identifier:332278161
NCBI Gene ID:2647
NCBI Accession:P78537.2
UniProt Secondary Accession:P78537,Q6NZ45, A1L4Q9,
UniProt Related Accession:P78537
Molecular Weight:153
NCBI Full Name:Biogenesis of lysosome-related organelles complex 1 subunit 1
NCBI Synonym Full Names:biogenesis of lysosomal organelles complex-1, subunit 1
NCBI Official Symbol:BLOC1S1  
NCBI Official Synonym Symbols:RT14; BLOS1; MICoA; GCN5L1  
NCBI Protein Information:biogenesis of lysosome-related organelles complex 1 subunit 1; BLOC subunit 1; BLOC-1 subunit 1; GCN5-like protein 1; MTA1-interacting coactivator; GCN5 general control of amino-acid synthesis 5-like 1; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1
UniProt Protein Name:Biogenesis of lysosome-related organelles complex 1 subunit 1
UniProt Synonym Protein Names:GCN5-like protein 1; Protein RT14
Protein Family:Biogenesis of lysosome-related organelles complex
UniProt Gene Name:BLOC1S1  
UniProt Entry Name:BL1S1_HUMAN
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