Cell Biology Antibodies 8
Anti-BGN Antibody (CAB3137)
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- SKU:
- CAB3137
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BGN Antibody |
| Antibody SKU: | CAB3137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human BGN (NP_001702.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human BGN (NP_001702.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EQRG FWDF TLDD GPFM MNDE EASG ADTS GVLD PDSV TPTY SAMC PFGC HCHL RVVQ CSDL GLKS VPKE ISPD TTLL DLQN NDIS ELRK DDFK GLQH LYAL VLVN NKIS KIHE KAFS PLRK LQKL YISK NHLV EIPP NLPS SLVE LRIH DNRI RKVP KGVF SGLR NMNC IEMG GNPL ENSG FEPG AFDG LKLN YLRI SEAK LTGI PKDL PET |
| Gene ID: | 633 |
| Uniprot: | P21810 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | BGN, DSPG1, MRLS, PG-S1, PGI, SEMDX, SLRR1A, biglycan |
| Background: | This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. |
| UniProt Protein Function: | BGN: May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xq28 Cellular Component: extracellular matrix; proteinaceous extracellular matrix; lysosomal lumen; transport vesicle; cell surface; Golgi lumen; extracellular region; sarcolemma Molecular Function:glycosaminoglycan binding; extracellular matrix binding; extracellular matrix structural constituent Biological Process: chondroitin sulfate metabolic process; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; pathogenesis; blood vessel remodeling; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; dermatan sulfate biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P21810 |
| NCBI GenInfo Identifier: | 266762 |
| NCBI Gene ID: | 633 |
| NCBI Accession: | P21810.2 |
| UniProt Secondary Accession: | P21810,P13247, D3DWU3, |
| UniProt Related Accession: | P21810 |
| Molecular Weight: | 368 |
| NCBI Full Name: | Biglycan |
| NCBI Synonym Full Names: | biglycan |
| NCBI Official Symbol: | BGN |
| NCBI Official Synonym Symbols: | PGI; DSPG1; PG-S1; SLRR1A |
| NCBI Protein Information: | biglycan; biglycan proteoglycan; bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; small leucine-rich protein 1A; dermatan sulphate proteoglycan I |
| UniProt Protein Name: | Biglycan |
| UniProt Synonym Protein Names: | Bone/cartilage proteoglycan I; PG-S1 |
| Protein Family: | Biglycan |
| UniProt Gene Name: | BGN |
| UniProt Entry Name: | PGS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BGN antibody (CAB3137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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