Signal Transduction Antibodies 3
Anti-BGLAP Antibody (CAB18241)
- SKU:
- CAB18241
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-BGLAP Antibody |
| Antibody SKU: | CAB18241 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human BGLAP. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse lung, Rat brain, Rat lung, Rat spleen |
| Immunogen: | Recombinant protein of human BGLAP. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 632 |
| Uniprot: | P02818 |
| Cellular Location: | |
| Calculated MW: | 11kDa |
| Observed MW: | 11kDa |
 | Western blot - BGLAP Polyclonal Antibody (CAB18241) |
| Synonyms: | BGLAP, BGP, OC, OCN, osteocalcin |
| Background: | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. |
| UniProt Protein Function: | osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 1q22 Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon Molecular Function:structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; osteoblast differentiation; odontogenesis; response to vitamin D; regulation of osteoclast differentiation; response to ethanol; response to vitamin K; response to zinc ion; response to mechanical stimulus; response to estrogen stimulus; response to hydroxyisoflavone; response to activity; cell adhesion; skeletal development; regulation of bone mineralization |
| NCBI Summary: | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015] |
| UniProt Code: | P02818 |
| NCBI GenInfo Identifier: | 129253 |
| NCBI Gene ID: | 632 |
| NCBI Accession: | P02818.2 |
| UniProt Secondary Accession: | P02818,Q5TCK6, |
| UniProt Related Accession: | P02818 |
| Molecular Weight: | 10,963 Da |
| NCBI Full Name: | Osteocalcin |
| NCBI Synonym Full Names: | bone gamma-carboxyglutamate (gla) protein |
| NCBI Official Symbol: | BGLAP |
| NCBI Official Synonym Symbols: | OC; BGP; OCN |
| NCBI Protein Information: | osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin) |
| UniProt Protein Name: | Osteocalcin |
| UniProt Synonym Protein Names: | Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein |
| Protein Family: | Osteocalcin |
| UniProt Gene Name: | BGLAP |
| UniProt Entry Name: | OSTCN_HUMAN |
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