Immunology Antibodies 3
Anti-BECN1 Antibody (CAB17028)
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- SKU:
- CAB17028
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-BECN1 Antibody |
| Antibody SKU: | CAB17028 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human BECN1 (NP_003757.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HeLa, HepG2, mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human BECN1 (NP_003757.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEGS KTSN NSTM QVSF VCQR CSQP LKLD TSFK ILDR VTIQ ELTA PLLT TAQA KPGE TQEE ETNS GEEP FIET PRQD GVSR RFIP PARM MSTE SANS FTLI GEAS DGGT MENL SRRL KVTG DLFD IMSG QTDV DHPL CEEC TDTL LDQL DTQL NVTE NECQ NYKR CLEI LEQM NEDD SEQL QMEL KELA LEEE RLIQ ELED VEKN RKIV AENL EKVQ AEAE RLDQ EEAQ YQRE YSEF KRQQ LELD DELK SVEN QMRY AQTQ LDKL KKTN VFNA TFHI WHSG |
| Gene ID: | 8678 |
| Uniprot: | Q14457 |
| Cellular Location: | |
| Calculated MW: | 51kDa |
| Observed MW: | 60kDa |
 | Western blot - BECN1 Polyclonal Antibody (CAB17028) |
| Synonyms: | ATG6, VPS30, beclin1, Beclin 1, BECN1, beclin-1 |
| Background: | This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Autophagy; Membrane protein, peripheral Chromosomal Location of Human Ortholog: 17q21 Cellular Component: extrinsic to membrane; mitochondrion; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; phagocytic vesicle; trans-Golgi network; nucleus; endosome Molecular Function:protein binding; phosphoinositide 3-kinase binding Biological Process: response to drug; viral reproduction; late endosome to vacuole transport; cytokinesis; CVT pathway; cellular response to nitrogen starvation; negative regulation of cell proliferation; response to vitamin E; lysosome organization and biogenesis; regulation of catalytic activity; beta-amyloid metabolic process; mitochondrion degradation; response to hypoxia; cellular defense response; neuron development; defense response to virus; positive regulation of macroautophagy; positive regulation of autophagy; negative regulation of apoptosis; autophagic vacuole formation |
| NCBI Summary: | Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010] |
| UniProt Code: | Q14457 |
| NCBI GenInfo Identifier: | 4680381 |
| NCBI Gene ID: | 8678 |
| NCBI Accession: | AAD27650.1 |
| UniProt Secondary Accession: | Q14457,O75595, Q9UNA8, |
| UniProt Related Accession: | Q14457 |
| Molecular Weight: | 51,896 Da |
| NCBI Full Name: | beclin 1 |
| NCBI Synonym Full Names: | beclin 1, autophagy related |
| NCBI Official Symbol: | BECN1 |
| NCBI Official Synonym Symbols: | ATG6; VPS30; beclin1 |
| NCBI Protein Information: | beclin-1; ATG6 autophagy related 6 homolog; coiled-coil myosin-like BCL2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein) |
| UniProt Protein Name: | Beclin-1 |
| UniProt Synonym Protein Names: | Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 |
| Protein Family: | Beclin |
| UniProt Gene Name: | BECN1 |
| UniProt Entry Name: | BECN1_HUMAN |
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