Cell Biology Antibodies 13
Anti-Bcl9 Antibody (CAB17209)
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- SKU:
- CAB17209
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Bcl9 Antibody |
| Antibody SKU: | CAB17209 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of mouse Bcl9. |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of mouse Bcl9. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 77578 |
| Uniprot: | Q9D219 |
| Cellular Location: | Nucleus |
| Calculated MW: | 148kDa |
| Observed MW: | Refer to figures |
| Synonyms: | BCL9, LGS, Bcl9 |
| Background: | BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. |
| UniProt Protein Function: | Bcl-9: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity. A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. Belongs to the BCL9 family. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein Cellular Component: Golgi apparatus; cis-Golgi network; cytoplasm; nucleus Molecular Function:beta-catenin binding Biological Process: Wnt receptor signaling pathway; somatic stem cell maintenance; myotube differentiation involved in skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin |
| UniProt Code: | Q9D219 |
| NCBI GenInfo Identifier: | 76363505 |
| NCBI Gene ID: | 77578 |
| NCBI Accession: | Q9D219.3 |
| UniProt Secondary Accession: | Q9D219,Q67FX9, Q8BUJ8, Q8VE74, B2RQC0, |
| UniProt Related Accession: | Q9D219 |
| Molecular Weight: | 1425 |
| NCBI Full Name: | B-cell CLL/lymphoma 9 protein |
| NCBI Synonym Full Names: | B cell CLL/lymphoma 9 |
| NCBI Official Symbol: | Bcl9 |
| NCBI Official Synonym Symbols: | Gm130; 2610202E01Rik; 8030475K17Rik; A330041G23Rik |
| NCBI Protein Information: | B-cell CLL/lymphoma 9 protein; bcl-9; B-cell lymphoma 9 protein; nuclear co-factor of beta-catenin signalling |
| UniProt Protein Name: | B-cell CLL/lymphoma 9 protein |
| Protein Family: | B-cell CLL/lymphoma 9 protein |
| UniProt Gene Name: | Bcl9 |
| UniProt Entry Name: | BCL9_MOUSE |
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