Epigenetics & Nuclear Signaling Antibodies 1
Anti-BCL3 Antibody (CAB11582)
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- SKU:
- CAB11582
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-BCL3 Antibody |
| Antibody SKU: | CAB11582 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human BCL3 (NP_005169.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, 293T |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human BCL3 (NP_005169.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ANVN AQMY SGSS ALHS ASGR GLLP LVRT LVRS GADS SLKN CHND TPLM VARS RRVI DILR GKAT RPAS TSQP DPSP DRSA NTSP ESSS RLSS NGLL SASP S |
| Gene ID: | 602 |
| Uniprot: | P20749 |
| Cellular Location: | Cytoplasm, Nucleus, perinuclear region |
| Calculated MW: | 47kDa |
| Observed MW: | 60kDa |
| Synonyms: | BCL3, BCL4, D19S37 |
| Background: | This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. |
| UniProt Protein Function: | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. |
| NCBI Summary: | This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20749 |
| NCBI GenInfo Identifier: | 294862410 |
| NCBI Gene ID: | 602 |
| NCBI Accession: | P20749.2 |
| UniProt Related Accession: | P20749 |
| Molecular Weight: | 48kDa |
| NCBI Full Name: | B-cell lymphoma 3 protein |
| NCBI Synonym Full Names: | B-cell CLL/lymphoma 3 |
| NCBI Official Symbol: | BCL3 |
| NCBI Official Synonym Symbols: | BCL4; D19S37 |
| NCBI Protein Information: | B-cell lymphoma 3 protein |
| UniProt Protein Name: | B-cell lymphoma 3 protein |
| UniProt Synonym Protein Names: | Proto-oncogene BCL3 |
| Protein Family: | B-cell lymphoma 3 protein |
| UniProt Gene Name: | BCL3 |
 | Western blot analysis of extracts of various cell lines, using BCL3 antibody (CAB11582) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of NIH/3T3 cells using BCL3 Rabbit pAb (CAB11582) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using BCL3 Rabbit pAb (CAB11582) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of C6 cells using BCL3 Rabbit pAb (CAB11582) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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