Anti-BCL2L12 Antibody (CAB19808)
- SKU:
- CAB19808
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Product Name: | BCL2L12 Rabbit mAb |
| Product Code: | CAB19808 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human BCL2L12 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | MCF7, PC-3 |
| Immunogen: | A synthesized peptide derived from human BCL2L12 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 83596 |
| Uniprot: | Q9HB09 |
| Calculated MW: | 32kDa |
| Observed MW: | 32KDa |
| UniProt Protein Function: | Bcl-2L12: belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]Protein type: ApoptosisChromosomal Location of Human Ortholog: 19q13.3Cellular Component: membrane; nucleusBiological Process: positive regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9HB09 |
| NCBI GenInfo Identifier: | 23396468 |
| NCBI Gene ID: | 83596 |
| NCBI Accession: | Q9HB09.1 |
| UniProt Secondary Accession: | Q9HB09,Q3SY11, Q3SY13, Q96I96, Q9HB08 |
| UniProt Related Accession: | Q9HB09 |
| Molecular Weight: | 36,665 Da |
| NCBI Full Name: | Bcl-2-like protein 12 |
| NCBI Synonym Full Names: | BCL2 like 12 |
| NCBI Official Symbol: | BCL2L12 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | bcl-2-like protein 12 |
| UniProt Protein Name: | Bcl-2-like protein 12 |
| UniProt Synonym Protein Names: | Bcl-2-related proline-rich protein |
| Protein Family: | Bcl-2-like protein |
| UniProt Gene Name: | BCL2L12 |
| UniProt Entry Name: | B2L12_HUMAN |
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