Cell Biology Antibodies 14
Anti-BCL2L10 Antibody (CAB17068)
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- SKU:
- CAB17068
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BCL2L10 Antibody |
| Antibody SKU: | CAB17068 |
| Antibody Size: | 20uL, 50 uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 11-140 of human BCL2L10 (NP_065129.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 11-140 of human BCL2L10 (NP_065129.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADP LRER TELL LADY LGYC AREP GTPE PAPS TPEA AVLR SAAA RLRQ IHRS FFSA YLGY PGNR FELV ALMA DSVL SDSP GPTW GRVV TLVT FAGT LLER GPLV TARW KKWG FQPR LKEQ EGDV ARDC QR |
| Gene ID: | 10017 |
| Uniprot: | Q9HD36 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | BCL2L10, BCL-B, Boo, Diva, bcl2-L-10 |
| Background: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. |
| UniProt Protein Function: | BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 15q21 Cellular Component: mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; integral to membrane; cytosol Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HD36 |
| NCBI GenInfo Identifier: | 13898394 |
| NCBI Gene ID: | 10017 |
| NCBI Accession: | AAK48715.1 |
| UniProt Secondary Accession: | Q9HD36,Q3SX80, Q52LQ9, Q8TCS9, |
| UniProt Related Accession: | Q9HD36 |
| Molecular Weight: | 23 kDa |
| NCBI Full Name: | BCLB |
| NCBI Synonym Full Names: | BCL2-like 10 (apoptosis facilitator) |
| NCBI Official Symbol: | BCL2L10 |
| NCBI Official Synonym Symbols: | Boo; Diva; BCL-B; bcl2-L-10 |
| NCBI Protein Information: | bcl-2-like protein 10 |
| UniProt Protein Name: | Bcl-2-like protein 10 |
| UniProt Synonym Protein Names: | Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B |
| UniProt Gene Name: | BCL2L10 |
| UniProt Entry Name: | B2L10_HUMAN |
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