Cell Death Antibodies 2
Anti-Bcl10 Antibody (CAB4520)
- SKU:
- CAB4520
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CARMEN
- Synonyms:
- CIPER
- Synonyms:
- CLAP
- Synonyms:
- IMD37
- Synonyms:
- c-E10
- Synonyms:
- mE10
- Research Area:
- Cell Death
Description
| Product Name: | Bcl10 Rabbit mAb |
| Product Code: | CAB4520 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CARMEN, CIPER, CLAP, IMD37, c-E10, mE10 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Bcl10 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562, Raji |
| Immunogen: | A synthesized peptide derived from human Bcl10 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8915 |
| Uniprot: | O95999 |
| Cellular Location: | Cytoplasm, Membrane raft, perinuclear region |
| Calculated MW: | 31kDa |
| Observed MW: | 30KDa |
| UniProt Protein Function: | Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer. |
| UniProt Protein Details: | Protein type:Apoptosis; Tumor suppressor; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p22 Cellular Component: CBM complex; protein complex; lysosome; immunological synapse; cytosol; lipid raft; T cell receptor complex; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; nucleus Molecular Function:protein C-terminus binding; protein kinase B binding; ubiquitin binding; protease binding; protein self-association; transcription coactivator activity; transcription factor binding; protein kinase binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; B cell apoptosis; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; lymphotoxin A biosynthetic process; regulation of T cell receptor signaling pathway; neural tube closure; toll-like receptor signaling pathway; innate immune response; cellular defense response; positive regulation of mast cell cytokine production; positive regulation of T cell activation; immunoglobulin mediated immune response; positive regulation of phosphorylation Disease: Follicular Lymphoma, Susceptibility To, 1; Mesothelioma, Malignant; Gastric Lymphoma, Primary; Testicular Germ Cell Tumor; Immunodeficiency 37 |
| NCBI Summary: | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95999 |
| NCBI GenInfo Identifier: | 4502379 |
| NCBI Gene ID: | 8915 |
| NCBI Accession: | NP_003912.1 |
| UniProt Secondary Accession: | O95999,Q5VUF1, |
| UniProt Related Accession: | O95999 |
| Molecular Weight: | 26,252 Da |
| NCBI Full Name: | B-cell lymphoma/leukemia 10 |
| NCBI Synonym Full Names: | B-cell CLL/lymphoma 10 |
| NCBI Official Symbol: | BCL10 |
| NCBI Official Synonym Symbols: | CLAP; mE10; CIPER; c-E10; CARMEN |
| NCBI Protein Information: | B-cell lymphoma/leukemia 10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing prote |
| UniProt Protein Name: | B-cell lymphoma/leukemia 10 |
| UniProt Synonym Protein Names: | B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10 |
| Protein Family: | B-cell lymphoma/leukemia |
| UniProt Gene Name: | BCL10 |
| UniProt Entry Name: | BCL10_HUMAN |
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