Cell Biology Antibodies 12

Anti-BCAN Antibody (CAB9368)

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SKU:
CAB9368
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-BCAN Antibody
Antibody SKU:CAB9368
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:MCF7, K-562, Raji, HeLa, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VPLL YENW NPGQ PDSY FLSG ENCV VMVW HDQG QWSD VPCN YHLS YTCK MGLV SCGP PPEL PLAQ VFGR PRLR YEVD TVLR YRCR EGLA QRNL PLIR CQEN GRWE APQI SCVP RRPA RALH PEED PEGR QGRL LGRW KALL IPPS SPMP GP
Gene ID:63827
Uniprot:Q96GW7
Cellular Location:GPI-anchor, Lipid-anchor, Membrane, Secreted, extracellular matrix, extracellular space
Calculated MW:71kDa/99kDa
Observed MW:110kDa
Synonyms:BCAN, BEHAB, CSPG7, brevican
Background:This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function:extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding

Biological Process: extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; hippocampus development; pathogenesis; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; chondroitin sulfate catabolic process; carbohydrate metabolic process; cell adhesion; skeletal development

NCBI Summary:This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
UniProt Code:Q96GW7
NCBI GenInfo Identifier:38372935
NCBI Gene ID:63827
NCBI Accession:NP_068767.3
UniProt Secondary Accession:Q96GW7,Q5SZ10, Q5T3I5, Q8TBB9, Q9HBK1, Q9HBK4, D3DVC2
UniProt Related Accession:Q96GW7
Molecular Weight:
NCBI Full Name:brevican core protein isoform 1
NCBI Synonym Full Names:brevican
NCBI Official Symbol:BCAN  
NCBI Official Synonym Symbols:BEHAB; CSPG7  
NCBI Protein Information:brevican core protein; chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; brain-enriched hyaluronan-binding protein
UniProt Protein Name:Brevican core protein
UniProt Synonym Protein Names:Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Protein Family:Brevican core protein
UniProt Gene Name:BCAN  
UniProt Entry Name:PGCB_HUMAN
Anti-BCAN Polyclonal Antibody (CAB9368)Western blot analysis of extracts of various cell lines, using BCAN antibody (CAB9368) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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system_update_altDatasheetHuman BCAN Recombinant Protein Brevican Core Protein (BCAN) is a secreted protein that belongs to the aggrecan/versican proteoglycan family. BCAN contains one C-type lec