Cell Biology Antibodies 5
Anti-BCAM Antibody (CAB14748)
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- SKU:
- CAB14748
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BCAM Antibody |
| Antibody SKU: | CAB14748 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 352-547 of human BCAM (NP_005572.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | U-251MG, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 352-547 of human BCAM (NP_005572.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KTLE LRVA YLDP LELS EGKV LSLP LNSS AVVN CSVH GLPT PALR WTKD STPL GDGP MLSL SSIT FDSN GTYV CEAS LPTV PVLS RTQN FTLL VQGS PELK TAEI EPKA DGSW REGD EVTL ICSA RGHP DPKL SWSQ LGGS PAEP IPGR QGWV SSSL TLKV TSAL SRDG ISCE ASNP HGNK RHVF HFGT VSPQ TSQA |
| Gene ID: | 4059 |
| Uniprot: | P50895 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 67kDa |
| Observed MW: | 100kDa |
| Synonyms: | BCAM, AU, CD239, LU, MSK19 |
| Background: | This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Laminin alpha-5 receptor. May mediate intracellular signaling. |
| NCBI Summary: | This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | P50895 |
| NCBI GenInfo Identifier: | 92058724 |
| NCBI Gene ID: | 4059 |
| NCBI Accession: | P50895.2 |
| UniProt Secondary Accession: | P50895,Q86VC7, A8MYF9, A9YWT5, A9YWT6, |
| UniProt Related Accession: | P50895 |
| Molecular Weight: | 67,405 Da |
| NCBI Full Name: | Basal cell adhesion molecule |
| NCBI Synonym Full Names: | basal cell adhesion molecule (Lutheran blood group) |
| NCBI Official Symbol: | BCAM |
| NCBI Official Synonym Symbols: | AU; LU; CD239; MSK19 |
| NCBI Protein Information: | basal cell adhesion molecule |
| UniProt Protein Name: | Basal cell adhesion molecule |
| UniProt Synonym Protein Names: | Auberger B antigen; B-CAM cell surface glycoprotein; F8/G253 antigen; Lutheran antigen; Lutheran blood group glycoprotein; CD_antigen: CD239 |
| Protein Family: | Basal cell adhesion molecule |
| UniProt Gene Name: | BCAM |
 | Western blot analysis of extracts of various cell lines, using BCAM antibody (CAB14748) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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