Metabolism Antibodies 2
Anti-BBOX1 Antibody (CAB5810)
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- SKU:
- CAB5810
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-BBOX1 Antibody |
| Antibody SKU: | CAB5810 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human BBOX1 (NP_003977.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, MCF7, BT-474, Mouse liver, Mouse kidney, Mouse spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human BBOX1 (NP_003977.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MACT IQKA EALD GAHL MQIL WYDE EESL YPAV WLRD NCPC SDCY LDSA KARK LLVE ALDV NIGI KGLI FDRK KVYI TWPD EHYS EFQA DWLK KRCF SKQA RAKL QREL FFPE CQYW GSEL QLPT LDFE DVLR YDEH AYKW LSTL KKVG IVRL TGAS DKPG EVSK LGKR MGFL YLTF YGHT |
| Gene ID: | 8424 |
| Uniprot: | O75936 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 44kDa |
| Observed MW: | 45kDa |
| Synonyms: | BBOX1, BBH, BBOX, G-BBH, gamma-BBH |
| Background: | This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. |
| UniProt Protein Function: | BBOX1: Catalyzes the formation of L-carnitine from gamma- butyrobetaine. Belongs to the gamma-BBH/TMLD family. |
| UniProt Protein Details: | Protein type:EC 1.14.11.1; Oxidoreductase; Amino Acid Metabolism - lysine degradation Chromosomal Location of Human Ortholog: 11p14.2 Cellular Component: mitochondrion; cytosol Molecular Function:gamma-butyrobetaine dioxygenase activity; zinc ion binding; iron ion binding Biological Process: carnitine biosynthetic process |
| NCBI Summary: | This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75936 |
| NCBI GenInfo Identifier: | 5915798 |
| NCBI Gene ID: | 8424 |
| NCBI Accession: | O75936.1 |
| UniProt Secondary Accession: | O75936,Q6IBJ2, B2R8L7, D3DQZ1, |
| UniProt Related Accession: | O75936 |
| Molecular Weight: | 387 |
| NCBI Full Name: | Gamma-butyrobetaine dioxygenase |
| NCBI Synonym Full Names: | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
| NCBI Official Symbol: | BBOX1 |
| NCBI Official Synonym Symbols: | BBH; BBOX; G-BBH; gamma-BBH |
| NCBI Protein Information: | gamma-butyrobetaine dioxygenase; gamma-butyrobetaine hydroxylase; gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 |
| UniProt Protein Name: | Gamma-butyrobetaine dioxygenase |
| UniProt Synonym Protein Names: | Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase |
| Protein Family: | Gamma-butyrobetaine dioxygenase |
| UniProt Gene Name: | BBOX1 |
| UniProt Entry Name: | BODG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BBOX1 antibody (CAB5810) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 150s. |
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